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Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice

1
Gunma University Heavy Ion Medical Center, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
2
Faculty and Graduate School of Health and Sports Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(12), 3959; https://doi.org/10.3390/ijms19123959
Received: 15 November 2018 / Revised: 5 December 2018 / Accepted: 7 December 2018 / Published: 9 December 2018
(This article belongs to the Special Issue Adaptation of Living Organisms in Space: From Mammals to Plants)
Although the body’s immune system is altered during spaceflight, the effects of microgravity (μG) on tumor growth and carcinogenesis are, as yet, unknown. To assess tumor proliferation and its effects on the immune system, we used a hind-limb unloading (HU) murine model to simulate μG during spaceflight. HU mice demonstrated significantly increased tumor growth, metastasis to the lung, and greater splenic and thymic atrophy compared with mice in constant orthostatic suspension and standard housing controls. In addition, mice undergoing temporary loading during HU (2 h per day) demonstrated no difference in cancer progression and immune organ atrophy compared with controls. Our findings suggest that temporary loading can prevent cancer progression and immune organ atrophy induced by HU. Further space experiment studies are warranted to elucidate the precise effects of μG on systemic immunity and cancer progression. View Full-Text
Keywords: tumor growth; metastasis; immune system; hind-limb unloading; animal model tumor growth; metastasis; immune system; hind-limb unloading; animal model
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MDPI and ACS Style

Takahashi, A.; Wakihata, S.; Ma, L.; Adachi, T.; Hirose, H.; Yoshida, Y.; Ohira, Y. Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice. Int. J. Mol. Sci. 2018, 19, 3959. https://doi.org/10.3390/ijms19123959

AMA Style

Takahashi A, Wakihata S, Ma L, Adachi T, Hirose H, Yoshida Y, Ohira Y. Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice. International Journal of Molecular Sciences. 2018; 19(12):3959. https://doi.org/10.3390/ijms19123959

Chicago/Turabian Style

Takahashi, Akihisa; Wakihata, Shoto; Ma, Liqiu; Adachi, Takuya; Hirose, Hiroki; Yoshida, Yukari; Ohira, Yoshinobu. 2018. "Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice" Int. J. Mol. Sci. 19, no. 12: 3959. https://doi.org/10.3390/ijms19123959

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