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Int. J. Mol. Sci. 2018, 19(12), 3756; https://doi.org/10.3390/ijms19123756

I’ve Gut A Feeling: Microbiota Impacting the Conceptual and Experimental Perspectives of Personalized Medicine

1
Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 03 50134, Firenze, Italy
2
Department of Biomedicine, Azienda Ospedaliera Universitaria Careggi (AOUC), Largo Brambilla, 03 50134, Firenze, Italy
*
Author to whom correspondence should be addressed.
Received: 21 September 2018 / Revised: 31 October 2018 / Accepted: 16 November 2018 / Published: 27 November 2018
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Abstract

In recent years, the human microbiota has gained increasing relevance both in research and clinical fields. Increasing studies seem to suggest the centrality of the microbiota and its composition both in the development and maintenance of what we call “health” and in generating and/or favoring (those cases in which the microbiota’s complex relational architecture is dysregulated) the onset of pathological conditions. The complex relationships between the microbiota and human beings, which invest core notions of biomedicine such as “health” and “individual,” do concern not only problems of an empirical nature but seem to require the need to adopt new concepts and new perspectives in order to be properly analysed and utilized, especially for their therapeutic implementation. In this contribution we report and discuss some of the theoretical proposals and innovations (from the ecological component to the notion of polygenomic organism) aimed at producing this change of perspective. In conclusion, we summarily analyze what impact and what new challenges these new approaches might have on personalized/person centred/precision medicine. View Full-Text
Keywords: microbiome; health; precision medicine; genomics microbiome; health; precision medicine; genomics
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Amedei, A.; Boem, F. I’ve Gut A Feeling: Microbiota Impacting the Conceptual and Experimental Perspectives of Personalized Medicine. Int. J. Mol. Sci. 2018, 19, 3756.

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