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Int. J. Mol. Sci. 2018, 19(11), 3603; https://doi.org/10.3390/ijms19113603

Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France

1
IUF-Leibniz Research Institute for Environmental Medicine, Auf´m Hennekamp 50, 40225 Düsseldorf, Germany
2
Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
3
Department of Environmental Health, Boston University School of Public Health, 72 East Concord Street, Boston, MA 02118, USA
4
Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
5
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
6
Toxicologie Pharmacologie et Signalisation Cellulaire, INSERM UMR-S1124, 45 rue des Saints-Pères, 75006 Paris, France
7
UFR des Sciences Fondamentales et Biomédicales, Université Paris Descartes, 45 rue des Saints-Pères, Sorbonne Paris Cité, 75006 Paris, France
*
Author to whom correspondence should be addressed.
Received: 6 November 2018 / Revised: 9 November 2018 / Accepted: 10 November 2018 / Published: 15 November 2018
(This article belongs to the Special Issue Aryl Hydrocarbon Receptor in Biology and Toxicology)
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Abstract

In a time where “translational” science has become a mantra in the biomedical field, it is reassuring when years of research into a biological phenomenon suddenly points towards novel prevention or therapeutic approaches to disease, thereby demonstrating once again that basic science and translational science are intimately linked. The studies on the aryl hydrocarbon receptor (AHR) discussed here provide a perfect example of how years of basic toxicological research on a molecule, whose normal physiological function remained a mystery for so long, has now yielded a treasure trove of actionable information on the development of targeted therapeutics. Examples are autoimmunity, metabolic imbalance, inflammatory skin and gastro-intestinal diseases, cancer, development and perhaps ageing. Indeed, the AHR field no longer asks, “What does this receptor do in the absence of xenobiotics?” It now asks, “What doesn’t this receptor do?”. View Full-Text
Keywords: transcription factor; translational science; environmental health; barrier organs; stem cells; nervous system; obesity; cancer; immunity; development; diet transcription factor; translational science; environmental health; barrier organs; stem cells; nervous system; obesity; cancer; immunity; development; diet
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Esser, C.; Lawrence, B.P.; Sherr, D.H.; Perdew, G.H.; Puga, A.; Barouki, R.; Coumoul, X. Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France. Int. J. Mol. Sci. 2018, 19, 3603.

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