Roles of Tristetraprolin in Tumorigenesis
Department of Biological Science, Dong-A University, Busan 49315, Korea
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(11), 3384; https://doi.org/10.3390/ijms19113384
Received: 5 October 2018
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Revised: 25 October 2018
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Accepted: 26 October 2018
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Published: 29 October 2018
(This article belongs to the Special Issue Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation)
Genetic loss or mutations in tumor suppressor genes promote tumorigenesis. The prospective tumor suppressor tristetraprolin (TTP) has been shown to negatively regulate tumorigenesis through destabilizing the messenger RNAs of critical genes implicated in both tumor onset and tumor progression. Regulation of TTP has therefore emerged as an important issue in tumorigenesis. Similar to other tumor suppressors, TTP expression is frequently downregualted in various human cancers, and its low expression is correlated with poor prognosis. Additionally, disruption in the regulation of TTP by various mechanisms results in the inactivation of TTP protein or altered TTP expression. A recent study showing alleviation of Myc-driven lymphomagenesis by the forced expression of TTP has shed light on new therapeutic avenues for cancer prevention and treatment through the restoration of TTP expression. In this review, we summarize key oncogenes subjected to the TTP-mediated mRNA degradation, and discuss how dysregulation of TTP can contribute to tumorigenesis. In addition, the control mechanism underlying TTP expression at the posttranscriptional and posttranslational levels will be discussed.
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Keywords:
tristetraprolin (TTP); tumorigenesis; posttranscriptional regulation; adenosine and uridine-rich elements (AREs)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Park, J.-M.; Lee, T.-H.; Kang, T.-H. Roles of Tristetraprolin in Tumorigenesis. Int. J. Mol. Sci. 2018, 19, 3384. https://doi.org/10.3390/ijms19113384
AMA Style
Park J-M, Lee T-H, Kang T-H. Roles of Tristetraprolin in Tumorigenesis. International Journal of Molecular Sciences. 2018; 19(11):3384. https://doi.org/10.3390/ijms19113384
Chicago/Turabian StylePark, Jeong-Min, Tae-Hee Lee, and Tae-Hong Kang. 2018. "Roles of Tristetraprolin in Tumorigenesis" International Journal of Molecular Sciences 19, no. 11: 3384. https://doi.org/10.3390/ijms19113384
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