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Article

Dietary Supplementation with Trihexanoin Enhances Intestinal Function of Weaned Piglets

1
Engineering Research Center of Feed Protein Resources on Agricultural By-products, Ministry of Education, Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China
2
Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China
3
Department of Animal Science, Texas A&M University, College Station, TX 77843, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 3277; https://doi.org/10.3390/ijms19103277
Received: 23 August 2018 / Revised: 9 October 2018 / Accepted: 15 October 2018 / Published: 22 October 2018
(This article belongs to the Special Issue Nutrition and Gut Health)
Trihexanoin is a short-chain triglyceride (SCT). Many studies have reported that SCTs play important roles in the maintenance of intestinal epithelial structure and function. The present work was to investigate the effects of trihexanoin on growth performance, carbohydrate and fat metabolism, as well as intestinal morphology and function in weaned piglets. Twenty weaned piglets (21 ± 2 d) were randomly allocated to one of two treatment groups: The control group (basal diet supplemented with 0.5% soya oil); the TH group (basal diet supplemented with 0.5% trihexanoin). Dietary trihexanoin supplementation significantly reduced diarrhea rate; increased the concentrations of LDL, HDL and total protein in plasma; decreased cholesterol concentrations and glutamyl transpeptidase activity in plasma; improved intestinal morphologic structure; altered the mRNA levels and abundances of proteins related to glycogen and fat metabolism, mucosal barrier function, antioxidant capacity and water transport capacity; and altered the community of intestinal microflora. These results indicate that dietary trihexanoin supplementation could reduce diarrhea, regulate carbohydrate and fat metabolism, exert beneficial effects on the intestinal mucosal barrier, protect the intestinal mucosa from injuries, improve intestinal transport and absorption, and enhance antioxidant capacity. In conclusion, dietary supplementation with 0.5% trihexanoin improves the intestinal function and health of weaned piglets. View Full-Text
Keywords: intestinal morphology and function; glycogen and fat metabolism; trihexanoin; weaned piglets intestinal morphology and function; glycogen and fat metabolism; trihexanoin; weaned piglets
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MDPI and ACS Style

Wu, T.; Li, K.; Yi, D.; Wang, L.; Zhao, D.; Lv, Y.; Zhang, L.; Chen, H.; Ding, B.; Hou, Y.; Wu, G. Dietary Supplementation with Trihexanoin Enhances Intestinal Function of Weaned Piglets. Int. J. Mol. Sci. 2018, 19, 3277. https://doi.org/10.3390/ijms19103277

AMA Style

Wu T, Li K, Yi D, Wang L, Zhao D, Lv Y, Zhang L, Chen H, Ding B, Hou Y, Wu G. Dietary Supplementation with Trihexanoin Enhances Intestinal Function of Weaned Piglets. International Journal of Molecular Sciences. 2018; 19(10):3277. https://doi.org/10.3390/ijms19103277

Chicago/Turabian Style

Wu, Tao; Li, Kang; Yi, Dan; Wang, Lei; Zhao, Di; Lv, Yang; Zhang, Lin; Chen, Hongbo; Ding, Binying; Hou, Yongqing; Wu, Guoyao. 2018. "Dietary Supplementation with Trihexanoin Enhances Intestinal Function of Weaned Piglets" Int. J. Mol. Sci. 19, no. 10: 3277. https://doi.org/10.3390/ijms19103277

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