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AMPK: An Epigenetic Landscape Modulator

by Brendan Gongol 1,2, Indah Sari 2,†, Tiffany Bryant 2,†, Geraldine Rosete 2,† and Traci Marin 1,3,*
Department of Medicine, University of California, San Diego, CA 92093, USA
Department of Cardiopulmonary Sciences, School of Allied Health Professions, Loma Linda University, Loma Linda, CA 92350, USA
Department of Health Sciences, Victor Valley College, Victorville, CA 92395, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(10), 3238;
Received: 26 September 2018 / Revised: 14 October 2018 / Accepted: 17 October 2018 / Published: 19 October 2018
(This article belongs to the Special Issue AMP-Activated Protein Kinase Signalling)
Activated by AMP-dependent and -independent mechanisms, AMP-activated protein kinase (AMPK) plays a central role in the regulation of cellular bioenergetics and cellular survival. AMPK regulates a diverse set of signaling networks that converge to epigenetically mediate transcriptional events. Reversible histone and DNA modifications, such as acetylation and methylation, result in structural chromatin alterations that influence transcriptional machinery access to genomic regulatory elements. The orchestration of these epigenetic events differentiates physiological from pathophysiological phenotypes. AMPK phosphorylation of histones, DNA methyltransferases and histone post-translational modifiers establish AMPK as a key player in epigenetic regulation. This review focuses on the role of AMPK as a mediator of cellular survival through its regulation of chromatin remodeling and the implications this has for health and disease. View Full-Text
Keywords: AMPK; epigenetics; chromatin remodeling; histone modification; DNA methylation AMPK; epigenetics; chromatin remodeling; histone modification; DNA methylation
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Gongol, B.; Sari, I.; Bryant, T.; Rosete, G.; Marin, T. AMPK: An Epigenetic Landscape Modulator. Int. J. Mol. Sci. 2018, 19, 3238.

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