AMPK: An Epigenetic Landscape Modulator
Abstract
:1. Introduction
2. Histone Modification
2.1. Histone Phosphorylation
2.2. Histone Acetylation
2.3. Histone Methylation
2.4. Histone O-GlcNAcylation
2.5. Histone Ribosylation
3. DNA Modification
DNA Methylation
4. Approaches to Elucidating the AMPK-Modulated Epigenetic Landscape
5. Conclusions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AMPK | AMP-activated protein kinase |
CPT1C | carnitine palmitoyltransferase 1C |
p21 | cyclin-dependent kinase inhibitor |
p53 | TP53 or tumor protein |
HAT | histone deacetylases |
acetyl-CoA | acetyl coenzyme-A |
HDAC | histone deacetylases |
AICAR | 5-Aminoimidazole-4-carboxamide ribonucleotide |
ACC | acetyl-CoA carboxylase |
ACSS2 | acetyl-CoA synthetase short-chain family member 2 |
TFEB | transcription factor EB |
SIRT | sirtuin |
NAD+ | nicotinamide adenine dinucleotide |
βOHB | β-hydroxybutyrate |
RBBP7 | retinoblastoma binding protein 7 |
PGC-1α | peroxisome proliferator-activated receptor gamma coactivator-1α |
Tfam | transcription factor A |
NRF | nuclear respiratory factors |
UCP | uncoupling proteins |
SAM | S-adenosyl methionine |
GLUT-4 | glucose transporter type 4 |
KDM2A | lysine-specific demethylase 2A |
KDM5 | demethyltransferase lysine demethylase 5 |
LSD1 | lysine-specific histone demethylase-1 |
PRC2 | polycomb repressive complex 2 |
COMPASS | complex proteins associated with Set1 |
EZH2 | enhancer of zeste homolog 2 |
Cdx2 | caudal type homeobox2 |
SLC5A8 | solute carrier family 5 member 8 |
O-GlcNAc | O-linked N-acetylglucosamine |
OGT | O-GlcNAc transferase |
UDP-GlcNAc | uridine diphosphate N-acetylglucosamine |
HBP | hexosamine biosynthesis pathway |
ART | mono-ADP ribosyltransferase |
PTM | Post translational modification |
PARP | poly-(ADP-ribose) polymerase |
Bcl-6 | B-cell Lymphoma protein 6 |
CpG | cytosine-guanine dinucleotides |
DNMT | DNA methyltransferase |
MBD | methyl-CpG binding domain proteins |
5-mC | 5-methycytosine |
5-hmC | 5-hydroxymethylcytosine |
5-fC | 5-formylcytosine |
5-caC | 5-carboxylcytosine |
TETs | ten-eleven translocation hydroxylases |
SAH | S-adenosylhomocysteine |
SHMT2 | serine hydroxymethyltransferase 2 |
SAHH | S-adenosylhomocysteine hydrolase |
COX4I | cytochrome C oxidase subunit 4I1 |
FABP3 | fatty acid binding protein 3 |
PPARδ | peroxisome proliferator-activated receptor δ |
TCA | tricarboxylic acid |
IDH2 | isocitrase dehydrogenase 2 |
IP-Seq | immunoprecipitation sequencing |
ATAC-seq | assay for transposase-accessible chromatin using sequencing |
GEO | gene expression omnibus |
SRA | sequence read archive |
dbSNP | single nucleotide polymorphism database |
3DGD | 3D genome database |
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Gongol, B.; Sari, I.; Bryant, T.; Rosete, G.; Marin, T. AMPK: An Epigenetic Landscape Modulator. Int. J. Mol. Sci. 2018, 19, 3238. https://doi.org/10.3390/ijms19103238
Gongol B, Sari I, Bryant T, Rosete G, Marin T. AMPK: An Epigenetic Landscape Modulator. International Journal of Molecular Sciences. 2018; 19(10):3238. https://doi.org/10.3390/ijms19103238
Chicago/Turabian StyleGongol, Brendan, Indah Sari, Tiffany Bryant, Geraldine Rosete, and Traci Marin. 2018. "AMPK: An Epigenetic Landscape Modulator" International Journal of Molecular Sciences 19, no. 10: 3238. https://doi.org/10.3390/ijms19103238