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Open AccessReview

Allogeneic Mesenchymal Stem Cells and Biomaterials: The Perfect Match for Cardiac Repair?

1
Laboratory of Regenerative Medicine, Foundation for Applied Medical Research, 31008 Pamplona, Spain
2
Department of Hematology and Cell Therapy, Clínica Universidad de Navarra, University of Navarra, 31008 Pamplona, Spain
3
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 3236; https://doi.org/10.3390/ijms19103236
Received: 24 September 2018 / Revised: 16 October 2018 / Accepted: 17 October 2018 / Published: 19 October 2018
(This article belongs to the Special Issue Cell-Biomaterial Interaction)
Coronary heart disease is the leading cause of death worldwide with huge socio-economic consequences. Cell therapy, and particularly mesenchymal stem cells (MSC), are considered a promising option to treat this disorder, due to their robust trophic and immunomodulatory properties. However, limitations such as their low rate of engraftment and poor survival after administration into the heart have precluded their large-scale clinical use. Nevertheless, the combination of MSC with polymer-made scaffolds or hydrogels has proven to enhance their retention and, therefore, their efficacy. Additionally, their allogeneic use could permit the creation of ready-to-use cell patches able to improve their feasibility and promote their application in clinical settings. In this review, the experimental and clinical results derived from the use of MSC in cardiac pathology, as well as advances in the bioengineering field to improve the potential of therapeutic cells, are extensively discussed. Additionally, the current understanding of the heart response to the allogeneic MSC transplants is addressed. View Full-Text
Keywords: myocardial infarction; biomaterials; mesenchymal stem cells; allogeneic patch myocardial infarction; biomaterials; mesenchymal stem cells; allogeneic patch
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MDPI and ACS Style

Perez-Estenaga, I.; Prosper, F.; Pelacho, B. Allogeneic Mesenchymal Stem Cells and Biomaterials: The Perfect Match for Cardiac Repair? Int. J. Mol. Sci. 2018, 19, 3236.

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