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The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration

Department of Physiology & Developmental Biology, Brigham Young University, Provo, UT 84602, USA
Int. J. Mol. Sci. 2018, 19(10), 3125; https://doi.org/10.3390/ijms19103125
Received: 28 September 2018 / Revised: 8 October 2018 / Accepted: 9 October 2018 / Published: 11 October 2018
(This article belongs to the Special Issue AMP-Activated Protein Kinase Signalling)
AMPK (5’-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its regulation of many downstream targets. Because of their effects on anabolic and catabolic cellular processes, AMPK plays an important role in the control of skeletal muscle development and growth. In this review, the effects of AMPK signaling, and those of its upstream activator, liver kinase B1 (LKB1), on skeletal muscle growth and atrophy are reviewed. The effect of AMPK activity on satellite cell-mediated muscle growth and regeneration after injury is also reviewed. Together, the current data indicate that AMPK does play an important role in regulating muscle mass and regeneration, with AMPKα1 playing a prominent role in stimulating anabolism and in regulating satellite cell dynamics during regeneration, and AMPKα2 playing a potentially more important role in regulating muscle degradation during atrophy. View Full-Text
Keywords: AMPK; LKB1; autophagy; proteasome; hypertrophy; atrophy; skeletal muscle; AICAR; mTOR; protein synthesis AMPK; LKB1; autophagy; proteasome; hypertrophy; atrophy; skeletal muscle; AICAR; mTOR; protein synthesis
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Thomson, D.M. The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration. Int. J. Mol. Sci. 2018, 19, 3125.

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