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Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation

by Claire L. Lyons 1,2 and Helen M. Roche 2,3,*
1
Unit of Molecular Metabolism, Lund University Diabetes Center, Clinical Research Center, Lund University, 205 02 Malmö, Sweden
2
Nutrigenomics Research Group, UCD Institute of Food and Health, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, 4 Dublin, Ireland
3
Institute of Global Food Security, Queen’s University Belfast BT7 1NN, Northern Ireland, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 3092; https://doi.org/10.3390/ijms19103092
Received: 7 September 2018 / Revised: 3 October 2018 / Accepted: 6 October 2018 / Published: 9 October 2018
(This article belongs to the Special Issue AMP-Activated Protein Kinase Signalling)
Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequent negative downstream effects on glucose, lipid and insulin metabolism. Nutrient stress in the form of obesity can impact AMPK and whole-body metabolism, leading to complications such as type 2 diabetes and cancer risk. There is a lack of data regarding the nature and extent that nutrient status has on AMPK and metabolic-inflammation. However, emerging work elucidates to a direct role of individual nutrients on AMPK and metabolic-inflammation, as a possible means of modulating AMPK activity. The posit being to use such nutritional agents to re-configure metabolic-inflammation towards more oxidative phosphorylation and promote the resolution of inflammation. The complex paradigm will be discussed within the context of if/how dietary components, nutrients including fatty acids and non-nutrient food components, such as resveratrol, berberine, curcumin and the flavonoid genistein, modulate AMPK dependent processes relating to inflammation and metabolism. View Full-Text
Keywords: AMPK; IL-1β; NLRP3; nutrition; dietary fatty acids; metabolic-inflammation; nutrigenomics AMPK; IL-1β; NLRP3; nutrition; dietary fatty acids; metabolic-inflammation; nutrigenomics
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Lyons, C.L.; Roche, H.M. Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation. Int. J. Mol. Sci. 2018, 19, 3092.

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