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Role of Extracellular Matrix in Development and Cancer Progression

Cellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, London SW7 2AZ, UK
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(10), 3028; https://doi.org/10.3390/ijms19103028
Received: 14 August 2018 / Revised: 27 September 2018 / Accepted: 28 September 2018 / Published: 4 October 2018
(This article belongs to the Special Issue Extracellular Matrix in Development and Disease)
The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The ECM’s composition and organization are spatiotemporally regulated to control cell behaviour and differentiation, but dysregulation of ECM dynamics leads to the development of diseases such as cancer. The chemical cues presented by the ECM have been appreciated as key drivers for both development and cancer progression. However, the mechanical forces present due to the ECM have been largely ignored but recently recognized to play critical roles in disease progression and malignant cell behaviour. Here, we review the ways in which biophysical forces of the microenvironment influence biochemical regulation and cell phenotype during key stages of human development and cancer progression. View Full-Text
Keywords: tumour microenvironment; cancer progression; extracellular matrix; matrix remodelling; fibrosis tumour microenvironment; cancer progression; extracellular matrix; matrix remodelling; fibrosis
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Walker, C.; Mojares, E.; Del Río Hernández, A. Role of Extracellular Matrix in Development and Cancer Progression. Int. J. Mol. Sci. 2018, 19, 3028.

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