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TIPE Family of Proteins and Its Implications in Different Chronic Diseases

1
Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India
2
Stem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6009, Australia
3
Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
4
Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China
5
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore
6
NUS Immunology Program, Life Sciences Institute, Centre for Life Sciences, National University of Singapore, Singapore 117456, Singapore
7
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
8
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
9
Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore 169610, Singapore
10
Medical Science Cluster, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore
11
Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA 6009, Australia
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 2974; https://doi.org/10.3390/ijms19102974
Received: 4 August 2018 / Revised: 19 September 2018 / Accepted: 22 September 2018 / Published: 29 September 2018
(This article belongs to the Special Issue Feature Annual Reviews in Molecular Sciences 2019)
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PDF [977 KB, uploaded 29 September 2018]
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Abstract

The tumor necrosis factor-α-induced protein 8-like (TIPE/TNFAIP8) family is a recently identified family of proteins that is strongly associated with the regulation of immunity and tumorigenesis. This family is comprised of four members, namely, tumor necrosis factor-α-induced protein 8 (TIPE/TNFAIP8), tumor necrosis factor-α-induced protein 8-like 1 (TIPE1/TNFAIP8L1), tumor necrosis factor-α-induced protein 8-like 2 (TIPE2/TNFAIP8L2), and tumor necrosis factor-α-induced protein 8-like 3 (TIPE3/TNFAIP8L3). Although the proteins of this family were initially described as regulators of tumorigenesis, inflammation, and cell death, they are also found to be involved in the regulation of autophagy and the transfer of lipid secondary messengers, besides contributing to immune function and homeostasis. Interestingly, despite the existence of a significant sequence homology among the four members of this family, they are involved in different biological activities and also exhibit remarkable variability of expression. Furthermore, this family of proteins is highly deregulated in different human cancers and various chronic diseases. This review summarizes the vivid role of the TIPE family of proteins and its association with various signaling cascades in diverse chronic diseases. View Full-Text
Keywords: TIPE; TIPE1; TIPE2; TIPE3; chronic diseases; cancer TIPE; TIPE1; TIPE2; TIPE3; chronic diseases; cancer
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Bordoloi, D.; Banik, K.; Shabnam, B.; Padmavathi, G.; Monisha, J.; Arfuso, F.; Dharmarajan, A.; Mao, X.; Lim, L.H.K.; Wang, L.; Fan, L.; Hui, K.M.; Kumar, A.P.; Sethi, G.; Kunnumakkara, A.B. TIPE Family of Proteins and Its Implications in Different Chronic Diseases. Int. J. Mol. Sci. 2018, 19, 2974.

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