Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis
Abstract
1. Introduction
2. Cardiovascular Comorbidities of Psoriasis and Psoriatic Arthritis
2.1. Cardiovascular Diseases
2.2. Cardiovascular Risk Factors and Metabolic Syndrome
3. Metabolic Syndrome, Atherosclerosis and Psoriasis/Psoriatic Arthritis: Common Inflammatory Pathways
4. Laboratory Biomarkers and Imaging of Subclinical Atherosclerosis
5. Therapeutic Intervention
5.1. Epidemiologic Evidence of Anti-Inflammatory Interventions on Cardiovascular Outcomes in Psoriasis/Psoriatic Arthritis (PsA)
5.2. Clinical Evidence
5.2.1. Effect of Anti-Inflammatory Interventions on Cardiovascular Outcomes
5.2.2. Effect of Anti-Inflammatory Interventions on Biomarkers/Imaging of Atherosclerosis
6. Conclusions
Conflicts of Interest
References
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First Author | Year | Disease | Number of Patients Treated with TNF-Inhibitors | Duration of Treatment between Assessments | Drug | Improvement of Flow Mediated Dilatation | Improvement in Pulse Wave Velocity | Impaired Progression of Intima Media Thickness |
---|---|---|---|---|---|---|---|---|
Avgerinou [128] | 2011 | Psoriasis | 14 | 12 weeks | ADA | YES | NO | NA |
Pina [129] | 2016 | Psoriasis | 29 | 6 months | ADA | YES | YES | NA |
Tam [130] | 2011 | PsA | 11 | 3 months | TNF inhibitors | NA | NA | YES |
Tam [130] | 2011 | PsA | 9 | 2 years | TNF inhibitors | NA | NA | NO |
Di Minno [131] | 2011 | PsA | 120 | 52, 24 months (mean, SD) | ADA, ETN, IFX | NA | NA | YES |
Ramonda [132] | 2014 | PsA | 32 | 2 years | ADA, ETN, IFX | NO | NA | NO |
Mazzoccoli [133] | 2010 | PsA, RA | 36 | 8–12 weeks | ETN, IFX | YES | NA | NO |
Angel [134] | 2011 | PsA, RA, AS | 17 | 8 weeks (previously treated for ≥1 year) | IFX | NA | NO | NA |
Angel [135] | 2012 | PsA, RA, AS | 36 | 1 year | ADA, ETN, IFX | NA | YES | YES |
Angel [136] | 2010 | PsA, RA, AS | 35 | 3 months | ADA, ETN, IFX | NA | YES | NA |
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Puig, L. Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis. Int. J. Mol. Sci. 2018, 19, 58. https://doi.org/10.3390/ijms19010058
Puig L. Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis. International Journal of Molecular Sciences. 2018; 19(1):58. https://doi.org/10.3390/ijms19010058
Chicago/Turabian StylePuig, Lluís. 2018. "Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis" International Journal of Molecular Sciences 19, no. 1: 58. https://doi.org/10.3390/ijms19010058
APA StylePuig, L. (2018). Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis. International Journal of Molecular Sciences, 19(1), 58. https://doi.org/10.3390/ijms19010058