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Scanning the Immunopathogenesis of Psoriasis

Dermatology Department, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1295 NW 14th St, Miami, FL 33125, USA
The Laboratory of Neuroimmunology, Fondazione Santa Lucia, Via del Fosso di Fiorano, 64, 00143 Rome, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(1), 179;
Received: 28 September 2017 / Revised: 3 January 2018 / Accepted: 4 January 2018 / Published: 8 January 2018
(This article belongs to the Special Issue Psoriasis)
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Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been profoundly revised following recent advances in the understanding of its pathophysiology. In the current model, a crosstalk between keratinocytes, neutrophils, mast cells, T cells, and dendritic cells is thought to create inflammatory and pro-proliferative circuits mediated by chemokines and cytokines. Various triggers, including recently identified autoantigens, Toll-like receptor agonists, chemerin, and thymic stromal lymphopoietin may activate the pathogenic cascade resulting in enhanced production of pro-inflammatory and proliferation-inducing mediators such as interleukin (IL)-17, tumor necrosis factor (TNF)-α, IL-23, IL-22, interferon (IFN)-α, and IFN-γ by immune cells. Among these key cytokines lie therapeutic targets for currently approved antipsoriatic therapies. This review aims to provide a comprehensive overview on the immune-mediated mechanisms characterizing the current pathogenic model of psoriasis. View Full-Text
Keywords: psoriasis; pathogenesis; immunology; autoantigen; IL-17; IL-23; cytokines; chemokines; autoreactive T cells; dendritic cells psoriasis; pathogenesis; immunology; autoantigen; IL-17; IL-23; cytokines; chemokines; autoreactive T cells; dendritic cells

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chiricozzi, A.; Romanelli, P.; Volpe, E.; Borsellino, G.; Romanelli, M. Scanning the Immunopathogenesis of Psoriasis. Int. J. Mol. Sci. 2018, 19, 179.

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