Deregulation of Frizzled Receptors in Hepatocellular Carcinoma
AbstractG protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a “cancer driver”. Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression. In hepatocellular carcinoma (HCC), the Wnt signaling pathway is frequently activated and it is associated with an aggressive HCC phenotype. Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed the deregulation of FZD receptors in HCC and their functional roles have been implicated in HCC progression. Given the important role of FZD receptors in HCC, we summarize here the expression pattern of FZD receptors in HCC and their corresponding functional roles during HCC progression. We also further review and highlight the potential targeting of FZD receptors as an alternative therapeutic strategy in HCC. View Full-Text
Share & Cite This Article
Chan, K.K.-S.; Lo, R.C.-L. Deregulation of Frizzled Receptors in Hepatocellular Carcinoma. Int. J. Mol. Sci. 2018, 19, 313.
Chan KK-S, Lo RC-L. Deregulation of Frizzled Receptors in Hepatocellular Carcinoma. International Journal of Molecular Sciences. 2018; 19(1):313.Chicago/Turabian Style
Chan, Kristy K.-S.; Lo, Regina C.-L. 2018. "Deregulation of Frizzled Receptors in Hepatocellular Carcinoma." Int. J. Mol. Sci. 19, no. 1: 313.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.