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Bio-Functional Design, Application and Trends in Metallic Biomaterials

School of Mechanical Engineering and Automation, Xihua University, Chengdu 610039, China
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
School of Manufacturing Science and Engineering, Sichuan University, Chengdu 610065, China
Department of Applied Mechanics, Sichuan University, Chengdu 610065, China
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(1), 24;
Received: 9 November 2017 / Revised: 27 November 2017 / Accepted: 12 December 2017 / Published: 22 December 2017
PDF [8103 KB, uploaded 22 December 2017]


Introduction of metals as biomaterials has been known for a long time. In the early development, sufficient strength and suitable mechanical properties were the main considerations for metal implants. With the development of new generations of biomaterials, the concepts of bioactive and biodegradable materials were proposed. Biological function design is very import for metal implants in biomedical applications. Three crucial design criteria are summarized for developing metal implants: (1) mechanical properties that mimic the host tissues; (2) sufficient bioactivities to form bio-bonding between implants and surrounding tissues; and (3) a degradation rate that matches tissue regeneration and biodegradability. This article reviews the development of metal implants and their applications in biomedical engineering. Development trends and future perspectives of metallic biomaterials are also discussed. View Full-Text
Keywords: metal implants; biomechanical design; porous structure; biodegradable metals; biological function design metal implants; biomechanical design; porous structure; biodegradable metals; biological function design

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Yang, K.; Zhou, C.; Fan, H.; Fan, Y.; Jiang, Q.; Song, P.; Fan, H.; Chen, Y.; Zhang, X. Bio-Functional Design, Application and Trends in Metallic Biomaterials. Int. J. Mol. Sci. 2018, 19, 24.

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