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Int. J. Mol. Sci. 2018, 19(1), 157; https://doi.org/10.3390/ijms19010157

Telomere Homeostasis: Interplay with Magnesium

1
Emergency Medicine Department, Glasgow Royal Infirmary, Glasgow G4 0SF, UK
2
Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G4 0SF, UK
3
Section of Epigenetics, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK
4
The Scottish Trace Element and Micronutrient Reference Laboratory, Department of Biochemistry, Royal Infirmary, Glasgow G31 2ER, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 24 November 2017 / Revised: 21 December 2017 / Accepted: 3 January 2018 / Published: 5 January 2018
(This article belongs to the Special Issue Role of Telomeres and Telomerase in Cancer and Aging)
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Abstract

Telomere biology, a key component of the hallmarks of ageing, offers insight into dysregulation of normative ageing processes that accompany age-related diseases such as cancer. Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also diminished during cellular senescence and normative physiological ageing. Inherent in the biochemistry of these processes is the role of magnesium, one of the main cellular ions and an essential cofactor in all reactions that use ATP. Magnesium plays an important role in many of the processes involved in regulating telomere structure, integrity and function. This review explores the mechanisms that maintain telomere structure and function, their influence on circadian rhythms and their impact on health and age-related disease. The pervasive role of magnesium in telomere homeostasis is also highlighted. View Full-Text
Keywords: telomeres; telomerase; TERT; mitochondria; oxidative stress; magnesium telomeres; telomerase; TERT; mitochondria; oxidative stress; magnesium
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Maguire, D.; Neytchev, O.; Talwar, D.; McMillan, D.; Shiels, P.G. Telomere Homeostasis: Interplay with Magnesium. Int. J. Mol. Sci. 2018, 19, 157.

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