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Int. J. Mol. Sci. 2017, 18(9), 1909;

Determination of Highly Sensitive Biological Cell Model Systems to Screen BPA-Related Health Hazards Using Pathway Studio

Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do 456-756, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 31 July 2017 / Revised: 4 September 2017 / Accepted: 4 September 2017 / Published: 6 September 2017
(This article belongs to the Special Issue Advances in the Research of Endocrine Disrupting Chemicals)
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Bisphenol-A (BPA) is a ubiquitous endocrine-disrupting chemical. Recently, many issues have arisen surrounding the disease pathogenesis of BPA. Therefore, several studies have been conducted to investigate the proteomic biomarkers of BPA that are associated with disease processes. However, studies on identifying highly sensitive biological cell model systems in determining BPA health risk are lacking. Here, we determined suitable cell model systems and potential biomarkers for predicting BPA-mediated disease using the bioinformatics tool Pathway Studio. We compiled known BPA-mediated diseases in humans, which were categorized into five major types. Subsequently, we investigated the differentially expressed proteins following BPA exposure in several cell types, and analyzed the efficacy of altered proteins to investigate their associations with BPA-mediated diseases. Our results demonstrated that colon cancer cells (SW480), mammary gland, and Sertoli cells were highly sensitive biological model systems, because of the efficacy of predicting the majority of BPA-mediated diseases. We selected glucose-6-phosphate dehydrogenase (G6PD), cytochrome b-c1 complex subunit 1 (UQCRC1), and voltage-dependent anion-selective channel protein 2 (VDAC2) as highly sensitive biomarkers to predict BPA-mediated diseases. Furthermore, we summarized proteomic studies in spermatozoa following BPA exposure, which have recently been considered as another suitable cell type for predicting BPA-mediated diseases. View Full-Text
Keywords: bisphenol-A (BPA) toxicity; cell model types; biomarker; pathway studio; spermatozoa bisphenol-A (BPA) toxicity; cell model types; biomarker; pathway studio; spermatozoa

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ryu, D.-Y.; Rahman, M.S.; Pang, M.-G. Determination of Highly Sensitive Biological Cell Model Systems to Screen BPA-Related Health Hazards Using Pathway Studio. Int. J. Mol. Sci. 2017, 18, 1909.

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