Next Article in Journal
Determination of Highly Sensitive Biological Cell Model Systems to Screen BPA-Related Health Hazards Using Pathway Studio
Next Article in Special Issue
The Beneficial Effects of Allicin in Chronic Kidney Disease Are Comparable to Losartan
Previous Article in Journal
Intestinal and Circulating MicroRNAs in Coeliac Disease
Previous Article in Special Issue
Effects of a New Nutraceutical Formulation (Berberine, Red Yeast Rice and Chitosan) on Non-HDL Cholesterol Levels in Individuals with Dyslipidemia: Results from a Randomized, Double Blind, Placebo-Controlled Study
Open AccessArticle

Dietary Phenethyl Isothiocyanate Protects Mice from Colitis Associated Colon Cancer

by Yi Liu and Moul Dey *
Department of Health and Nutritional Sciences, Box 2275A, South Dakota State University, Brookings, SD 56007, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(9), 1908;
Received: 30 June 2017 / Revised: 30 August 2017 / Accepted: 1 September 2017 / Published: 6 September 2017
(This article belongs to the Special Issue Nutraceuticals in Human Health and Disease)
We have previously reported alleviation of dextran sodium sulfate (DSS)-induced ulcerative colitis signs in phenethyl isothiocyanate (PEITC)-treated mice. Here we investigated chemoprotective activities of PEITC in mice with Azoxymethane-DSS induced colitis associated colon carcinogenesis. We also examined the molecular mediators associated with the PEITC effects using relevant cell lines. A 0.12% PEITC-enriched mouse-diet reduced mucosal and submucosal inflammation as well as glandular atypia by 12% and the frequency of adenocarcinoma by 17% with a concomitant improvement in overall disease activity indices compared to the diseased control group. Lipopolysaccharide-induced in vitro up-regulation of key mediators of inflammation, immune response, apoptosis, and cell proliferation were attenuated by 10 μM PEITC. Three of these mediators showed concentration-dependent reduction in respective mRNAs. Furthermore, PEITC inhibited Nuclear factor kappa B1 (NFκB1) proteins in a concentration-dependent manner. The NFκB1 mRNA expression inversely correlated (r = −0.940, p = 0.013) with tri-methylation of lysine 27 on histone 3 near its promoter region in a time-dependent manner. These results indicate that PEITC may slow down the development of colon carcinogenesis in an inflammatory intestinal setting which is potentially associated with epigenetic modulation of NFκB1 signaling. View Full-Text
Keywords: phenethyl isothiocyanate (PEITC); colitis associated colon cancer phenethyl isothiocyanate (PEITC); colitis associated colon cancer
Show Figures

Figure 1

MDPI and ACS Style

Liu, Y.; Dey, M. Dietary Phenethyl Isothiocyanate Protects Mice from Colitis Associated Colon Cancer. Int. J. Mol. Sci. 2017, 18, 1908.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop