Next Article in Journal
Treatment of the First Acute Relapse Following Therapeutic Plasma Exchange in Formerly Glucocorticosteroid-Unresponsive Multiple Sclerosis Patients—A Multicenter Study to Evaluate Glucocorticosteroid Responsiveness
Next Article in Special Issue
Protein Carbamylation: A Marker Reflecting Increased Age-Related Cell Oxidation
Previous Article in Journal
In Vitro Assays in Severe Cutaneous Adverse Drug Reactions: Are They Still Research Tools or Diagnostic Tests Already?
Previous Article in Special Issue
An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity
Open AccessReview

Markers of T Cell Senescence in Humans

by Weili Xu 1,2 and Anis Larbi 1,2,3,4,5,*
Biology of Aging Program and Immunomonitoring Platform, Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, Singapore 138648, Singapore
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
Department of Microbiology, National University of Singapore, Singapore 117597, Singapore
Department of Geriatrics, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC J1K 2R1, Canada
Faculty of Sciences, University ElManar, Tunis 1068, Tunisia
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(8), 1742;
Received: 31 May 2017 / Revised: 22 July 2017 / Accepted: 26 July 2017 / Published: 10 August 2017
(This article belongs to the Special Issue Immunology of Aging)
Many countries are facing the aging of their population, and many more will face a similar obstacle in the near future, which could be a burden to many healthcare systems. Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccination are important matters for researchers in the field of aging. As older adults show higher prevalence for a variety of diseases, this also implies higher risk of complications, including nosocomial infections, slower recovery and sequels that may reduce the autonomy and overall quality of life of older adults. The age-related effects on the immune system termed as “immunosenescence” can be exemplified by the reported hypo-responsiveness to influenza vaccination of the elderly. T cells, which belong to the adaptive arm of the immune system, have been extensively studied and the knowledge gathered enables a better understanding of how the immune system may be affected after acute/chronic infections and how this matters in the long run. In this review, we will focus on T cells and discuss the surface and molecular markers that are associated with T cell senescence. We will also look at the implications that senescent T cells could have on human health and diseases. Finally, we will discuss the benefits of having these markers for investigators and the future work that is needed to advance the field of T cell senescence markers. View Full-Text
Keywords: human aging; immunosenescence; immune system; T cells; senescence; markers; phenotyping human aging; immunosenescence; immune system; T cells; senescence; markers; phenotyping
Show Figures

Figure 1

MDPI and ACS Style

Xu, W.; Larbi, A. Markers of T Cell Senescence in Humans. Int. J. Mol. Sci. 2017, 18, 1742.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop