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Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders

Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy
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Int. J. Mol. Sci. 2017, 18(8), 1627; https://doi.org/10.3390/ijms18081627
Received: 20 June 2017 / Revised: 10 July 2017 / Accepted: 18 July 2017 / Published: 26 July 2017
(This article belongs to the Special Issue Microtubule-Targeting Agents)
Neurodevelopmental disorders (NDDs) are characterized by neuroanatomical abnormalities indicative of corticogenesis disturbances. At the basis of NDDs cortical abnormalities, the principal developmental processes involved are cellular proliferation, migration and differentiation. NDDs are also considered “synaptic disorders” since accumulating evidence suggests that NDDs are developmental brain misconnection syndromes characterized by altered connectivity in local circuits and between brain regions. Microtubules and microtubule-associated proteins play a fundamental role in the regulation of basic neurodevelopmental processes, such as neuronal polarization and migration, neuronal branching and synaptogenesis. Here, the role of microtubule dynamics will be elucidated in regulating several neurodevelopmental steps. Furthermore, the correlation between abnormalities in microtubule dynamics and some NDDs will be described. Finally, we will discuss the potential use of microtubule stabilizing agents as a new pharmacological intervention for NDDs treatment. View Full-Text
Keywords: neurodevelopmental disorders; microtubule; brain malformation; microtubule stabilizing agents neurodevelopmental disorders; microtubule; brain malformation; microtubule stabilizing agents
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Bonini, S.A.; Mastinu, A.; Ferrari-Toninelli, G.; Memo, M. Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders. Int. J. Mol. Sci. 2017, 18, 1627.

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