Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study
AbstractAcute erythroleukemia (AEL) is a rare disease typically associated with a poor prognosis. The median survival ranges between 3–9 months from initial diagnosis. Hypomethylating agents (HMAs) have been shown to prolong survival in patients with myelodysplastic syndromes (MDS) and AML, but there is limited data of their efficacy in AEL. We collected data from 210 AEL patients treated at 28 international sites. Overall survival (OS) and PFS were estimated using the Kaplan-Meier method and the log-rank test was used for subgroup comparisons. Survival between treatment groups was compared using the Cox proportional hazards regression model. Eighty-eight patients were treated with HMAs, 44 front line, and 122 with intensive chemotherapy (ICT). ICT led to a higher overall response rate (complete or partial) compared to first-line HMA (72% vs. 46.2%, respectively; p ≤ 0.001), but similar progression-free survival (8.0 vs. 9.4 months; p = 0.342). Overall survival was similar for ICT vs. HMAs (10.5 vs. 13.7 months; p = 0.564), but patients with high-risk cytogenetics treated with HMA first-line lived longer (7.5 for ICT vs. 13.3 months; p = 0.039). Our results support the therapeutic value of HMA in AEL. View Full-Text
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Almeida, A.M.; Prebet, T.; Itzykson, R.; Ramos, F.; Al-Ali, H.; Shammo, J.; Pinto, R.; Maurillo, L.; Wetzel, J.; Musto, P.; Van De Loosdrecht, A.A.; Costa, M.J.; Esteves, S.; Burgstaller, S.; Stauder, R.; Autzinger, E.M.; Lang, A.; Krippl, P.; Geissler, D.; Falantes, J.F.; Pedro, C.; Bargay, J.; Deben, G.; Garrido, A.; Bonanad, S.; Diez-Campelo, M.; Thepot, S.; Ades, L.; Sperr, W.R.; Valent, P.; Fenaux, P.; Sekeres, M.A.; Greil, R.; Pleyer, L. Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study. Int. J. Mol. Sci. 2017, 18, 837.
Almeida AM, Prebet T, Itzykson R, Ramos F, Al-Ali H, Shammo J, Pinto R, Maurillo L, Wetzel J, Musto P, Van De Loosdrecht AA, Costa MJ, Esteves S, Burgstaller S, Stauder R, Autzinger EM, Lang A, Krippl P, Geissler D, Falantes JF, Pedro C, Bargay J, Deben G, Garrido A, Bonanad S, Diez-Campelo M, Thepot S, Ades L, Sperr WR, Valent P, Fenaux P, Sekeres MA, Greil R, Pleyer L. Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study. International Journal of Molecular Sciences. 2017; 18(4):837.Chicago/Turabian Style
Almeida, Antonio M.; Prebet, Thomas; Itzykson, Raphael; Ramos, Fernando; Al-Ali, Haifa; Shammo, Jamile; Pinto, Ricardo; Maurillo, Luca; Wetzel, Jaime; Musto, Pellegrino; Van De Loosdrecht, Arjan A.; Costa, Maria J.; Esteves, Susana; Burgstaller, Sonja; Stauder, Reinhard; Autzinger, Eva M.; Lang, Alois; Krippl, Peter; Geissler, Dietmar; Falantes, Jose F.; Pedro, Carmen; Bargay, Joan; Deben, Guillermo; Garrido, Ana; Bonanad, Santiago; Diez-Campelo, Maria; Thepot, Sylvain; Ades, Lionel; Sperr, Wolfgang R.; Valent, Peter; Fenaux, Pierre; Sekeres, Mikkael A.; Greil, Richard; Pleyer, Lisa. 2017. "Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study." Int. J. Mol. Sci. 18, no. 4: 837.
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