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Lysozyme Associated Liposomal Gentamicin Inhibits Bacterial Biofilm

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China
Author to whom correspondence should be addressed.
Academic Editors: Antonella Piozzi and Iolanda Francolini
Int. J. Mol. Sci. 2017, 18(4), 784;
Received: 9 February 2017 / Revised: 3 April 2017 / Accepted: 4 April 2017 / Published: 9 April 2017
(This article belongs to the Special Issue Antimicrobial Polymers 2016)
PDF [10611 KB, uploaded 9 April 2017]


Bacteria on living or inert surfaces usually form biofilms which make them highly resistant to antibiotics and immune clearance. Herein, we develop a simple approach to overcome the above conundrum through lysozyme-associated liposomal gentamicin (LLG). The association of lysozyme to the surface of liposomes can effectively reduce the fusion of liposomes and undesirable payload release in regular storage or physiological environments. The LLG was more effective at damaging established biofilms and inhibiting biofilm formation of pathogens including Gram-positive and Gram-negative bacteria than gentamicin alone. This strategy may provide a novel approach to treat infections due to bacterial biofilm. View Full-Text
Keywords: liposome; lysozyme; gentamicin; biofilm liposome; lysozyme; gentamicin; biofilm

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Hou, Y.; Wang, Z.; Zhang, P.; Bai, H.; Sun, Y.; Duan, J.; Mu, H. Lysozyme Associated Liposomal Gentamicin Inhibits Bacterial Biofilm. Int. J. Mol. Sci. 2017, 18, 784.

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