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Correction published on 19 September 2017, see Int. J. Mol. Sci. 2017, 18(9), 2009.

Open AccessArticle
Int. J. Mol. Sci. 2017, 18(4), 780;

Bioactivity of NANOZR Induced by Alkali Treatment

Department of Removable Prosthodontics and Occlusion, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan
Department of Periodotology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan
Author to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 7 March 2017 / Revised: 28 March 2017 / Accepted: 2 April 2017 / Published: 6 April 2017
(This article belongs to the Collection Bioactive Nanoparticles)
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In recent years, zirconia has been a recognized implant material in clinical dentistry. In the present study, we investigated the performance of an alkali-modified ceria-stabilized tetragonal ZrO2 polycrystalline ceramic-based nanostructured zirconia/alumina composite (NANOZR) implant by assessing surface morphology and composition, wettability, bovine serum albumin adsorption rate, rat bone marrow (RBM) cell attachment, and capacity for inducing bone differentiation. NANOZR surfaces without and with alkali treatment served as the control and test groups, respectively. RBM cells were seeded in a microplate with the implant and cultured in osteogenic differentiation medium, and their differentiation was evaluated by measuring alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, calcium deposition, and osteogenic gene expression. The alkali-treated NANOZR surface increased ALP activity, OCN production, calcium deposition, and osteogenesis-related gene expression in attached RBM cells. These data suggest that alkali treatment enhances the osteogenesis-inducing capacity of NANOZR implants and may therefore improve their biointegration into alveolar bone. View Full-Text
Keywords: zirconia/alumina nano-composite; bioactivity; alkali treatment zirconia/alumina nano-composite; bioactivity; alkali treatment

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Nishizaki, M.; Komasa, S.; Taguchi, Y.; Nishizaki, H.; Okazaki, J. Bioactivity of NANOZR Induced by Alkali Treatment. Int. J. Mol. Sci. 2017, 18, 780.

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