The Development of a Novel Therapeutic Strategy to Target Hyaluronan in the Extracellular Matrix of Pancreatic Ductal Adenocarcinoma
Abstract
:1. Introduction
2. Hyaluronan and Its Role in Progression of Pancreatic Ductal Adenocarcinoma
3. The Discovery of 4-Methylumbelliferone as an Inhibitor of Hyaluronan Synthesis and Its Mechanism of Action
4. The Alteration of the Extracellular Matrix in Pancreatic Ductal Adenocarcinoma through Reduction of Hyaluronan
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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No. | Substance | Cells | Author (year) | Ref. |
---|---|---|---|---|
1. | anti-inflammatory steroids | Human skin fibroblasts | Saarni, H. et al. (1978) | [37] |
2. | Monensin | Rat fibrosarcoma cells | Goldberg, R.L. and Toole, B.P. (1983) | [38] |
3. | Cyclofenil diphemol | Rat chondrocytes | Mason, R.M. et al. (1984) | [39] |
4. | Periodae-oxidized UDP-GlcNAc | Human fibrosarcoma cells | Prehm P. (1985) | [40] |
5. | n-Butylate | Rat liver fat-storing cells | Gressner, A.M. and Haarmann, R. (1988) | [41] |
6. | Dexamethasone | Human skin fibroblasts | Smith, T.J. (1988) | [42] |
7. | All-trans retinoic acid | Human skin fibroblasts | Smith, T.J. (1990) | [43] |
8. | p-Nitrophenol-β-d-xyloside | Rat liver fat-storing cells | Gressner, A.M. (1991) | [44] |
9. | Genistein | Rabbit mesothelial cells | Honda, A. et al. (1991) | [45] |
10. | Suramin | Mouse skin fibroblasts | August, E.M. et al. (1993) | [46] |
11. | Vanadate | Mouse skin fibroblasts | Zaharevitz, D.W. et al. (1993) | [47] |
12. | 4-methylumbelliferone | Human skin fibroblasts | Nakamura, T. et al. (1995) | [48] |
13. | Fluoxetine, amitriptyline | Human synovial cells | Yaron, I. et al. (1999) | [49] |
14. | Vesnarinone | Human myofibroblasts | Ueki, N. et al. (2000) | [50] |
15. | Mannose | Human myofibroblasts | Jokela, T.A. et al. (2008) | [51] |
16. | Methyl-β-cyclodextrin | Human breast cancer cells | Kultti, A. et al. (2010) | [52] |
17. | Estradiol | Human vascular smooth muscle cells | Freudenberger, T. et al (2011) | [53] |
18. | Collagen fragments | Human skin fibroblasts | Röck, K. et al. (2011) | [54] |
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Kudo, D.; Suto, A.; Hakamada, K. The Development of a Novel Therapeutic Strategy to Target Hyaluronan in the Extracellular Matrix of Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci. 2017, 18, 600. https://doi.org/10.3390/ijms18030600
Kudo D, Suto A, Hakamada K. The Development of a Novel Therapeutic Strategy to Target Hyaluronan in the Extracellular Matrix of Pancreatic Ductal Adenocarcinoma. International Journal of Molecular Sciences. 2017; 18(3):600. https://doi.org/10.3390/ijms18030600
Chicago/Turabian StyleKudo, Daisuke, Akiko Suto, and Kenichi Hakamada. 2017. "The Development of a Novel Therapeutic Strategy to Target Hyaluronan in the Extracellular Matrix of Pancreatic Ductal Adenocarcinoma" International Journal of Molecular Sciences 18, no. 3: 600. https://doi.org/10.3390/ijms18030600