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A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

Institute of Medical Systems Biology, Guangdong Medical University, Dongguan 523808, China
Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan 523808, China
Institute for Systems Biology, Seattle, WC 98109, USA
Department of endocrinology, Zhongshan Chen Xinghai Hospital Affiliated to Guangdong Medical University, Zhongshan 528415, China
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Int. J. Mol. Sci. 2017, 18(3), 456;
Received: 26 December 2016 / Revised: 9 February 2017 / Accepted: 14 February 2017 / Published: 28 February 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
PDF [3216 KB, uploaded 28 February 2017]


MicroRNAs (miRNAs) are small noncoding RNAs that modulate the cellular transcriptome at the post-transcriptional level. miRNA plays important roles in different disease manifestation, including type 2 diabetes mellitus (T2DM). Many studies have characterized the changes of miRNAs in T2DM, a complex systematic disease; however, few studies have integrated these findings and explored the functional effects of the dysregulated miRNAs identified. To investigate the involvement of miRNAs in T2DM, we obtained and analyzed all relevant studies published prior to 18 October 2016 from various literature databases. From 59 independent studies that met the inclusion criteria, we identified 158 dysregulated miRNAs in seven different major sample types. To understand the functional impact of these deregulated miRNAs, we performed targets prediction and pathway enrichment analysis. Results from our analysis suggested that the altered miRNAs are involved in the core processes associated with T2DM, such as carbohydrate and lipid metabolisms, insulin signaling pathway and the adipocytokine signaling pathway. This systematic survey of dysregulated miRNAs provides molecular insights on the effect of deregulated miRNAs in different tissues during the development of diabetes. Some of these miRNAs and their mRNA targets may have diagnostic and/or therapeutic utilities in T2DM. View Full-Text
Keywords: microRNA; type 2 diabetes mellitus; miRNA-mRNA interaction network; systematic study microRNA; type 2 diabetes mellitus; miRNA-mRNA interaction network; systematic study

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He, Y.; Ding, Y.; Liang, B.; Lin, J.; Kim, T.-K.; Yu, H.; Hang, H.; Wang, K. A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus. Int. J. Mol. Sci. 2017, 18, 456.

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