Next Article in Journal
Essential Roles of E3 Ubiquitin Ligases in p53 Regulation
Next Article in Special Issue
Study of Different Variants of Mo Enzyme crARC and the Interaction with Its Partners crCytb5-R and crCytb5-1
Previous Article in Journal
Determination of VEGFR-2 (KDR) 604A>G Polymorphism in Pancreatic Disorders
Previous Article in Special Issue
The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(2), 440;

Matrix Metalloproteinases as Regulators of Periodontal Inflammation

Department of Conservative Dentistry, School of Dentistry, Universidad de Chile, Santiago 8380492, Chile
Department of Biological Sciences, School of Dentistry of Bauru, University of São Paulo (FOB/USP), Bauru, São Paulo 17012-901, Brazil
Center for Craniofacial Research, University of Texas School of Dentistry at Houston, Houston, TX 77054, USA
Department of Oral and Maxillofacial Diseases, Helsinki University and Helsinki University Central Hospital, Helsinki 00290, Finland
Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge 14183, Sweden
Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile
Dentistry Unit, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago 8910060, Chile
Author to whom correspondence should be addressed.
Academic Editor: Masatoshi Maki
Received: 12 January 2017 / Revised: 7 February 2017 / Accepted: 8 February 2017 / Published: 17 February 2017
(This article belongs to the Special Issue Metalloproteins 2017)
Full-Text   |   PDF [1124 KB, uploaded 17 February 2017]   |  


Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the ‘protease web’ is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules—such as cytokines, chemokines, and growth factors, among others—regulating their biological functions and/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation. View Full-Text
Keywords: MMPs; chronic periodontitis; periodontal inflammation regulation; modulation MMPs; chronic periodontitis; periodontal inflammation regulation; modulation

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Franco, C.; Patricia, H.-R.; Timo, S.; Claudia, B.; Marcela, H. Matrix Metalloproteinases as Regulators of Periodontal Inflammation. Int. J. Mol. Sci. 2017, 18, 440.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top