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Open AccessReview

The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders

by Yajin Liao 1,2, Yuan Dong 3 and Jinbo Cheng 2,*
1
The Brain Science Center, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing 100039, China
2
The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
3
Department of Biochemistry, Qingdao University Medical College, Qingdao 266071, China
*
Author to whom correspondence should be addressed.
Academic Editor: Masatoshi Maki
Int. J. Mol. Sci. 2017, 18(2), 248; https://doi.org/10.3390/ijms18020248
Received: 20 December 2016 / Revised: 17 January 2017 / Accepted: 18 January 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Metalloproteins 2017)
The mitochondrial calcium uniporter (MCU)—a calcium uniporter on the inner membrane of mitochondria—controls the mitochondrial calcium uptake in normal and abnormal situations. Mitochondrial calcium is essential for the production of adenosine triphosphate (ATP); however, excessive calcium will induce mitochondrial dysfunction. Calcium homeostasis disruption and mitochondrial dysfunction is observed in many neurodegenerative disorders. However, the role and regulatory mechanism of the MCU in the development of these diseases are obscure. In this review, we summarize the role of the MCU in controlling oxidative stress-elevated mitochondrial calcium and its function in neurodegenerative disorders. Inhibition of the MCU signaling pathway might be a new target for the treatment of neurodegenerative disorders. View Full-Text
Keywords: MCU; neurodegenerative disorder; inflammation; iron overload; oxidative stress MCU; neurodegenerative disorder; inflammation; iron overload; oxidative stress
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MDPI and ACS Style

Liao, Y.; Dong, Y.; Cheng, J. The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders. Int. J. Mol. Sci. 2017, 18, 248.

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