Next Article in Journal
AKT Axis, miR-21, and RECK Play Pivotal Roles in Dihydroartemisinin Killing Malignant Glioma Cells
Next Article in Special Issue
Matrix Metalloproteinases as Regulators of Periodontal Inflammation
Previous Article in Journal
Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin
Previous Article in Special Issue
Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer’s Disease
Open AccessReview

The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders

by Yajin Liao 1,2, Yuan Dong 3 and Jinbo Cheng 2,*
The Brain Science Center, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing 100039, China
The State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Department of Biochemistry, Qingdao University Medical College, Qingdao 266071, China
Author to whom correspondence should be addressed.
Academic Editor: Masatoshi Maki
Int. J. Mol. Sci. 2017, 18(2), 248;
Received: 20 December 2016 / Revised: 17 January 2017 / Accepted: 18 January 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Metalloproteins 2017)
The mitochondrial calcium uniporter (MCU)—a calcium uniporter on the inner membrane of mitochondria—controls the mitochondrial calcium uptake in normal and abnormal situations. Mitochondrial calcium is essential for the production of adenosine triphosphate (ATP); however, excessive calcium will induce mitochondrial dysfunction. Calcium homeostasis disruption and mitochondrial dysfunction is observed in many neurodegenerative disorders. However, the role and regulatory mechanism of the MCU in the development of these diseases are obscure. In this review, we summarize the role of the MCU in controlling oxidative stress-elevated mitochondrial calcium and its function in neurodegenerative disorders. Inhibition of the MCU signaling pathway might be a new target for the treatment of neurodegenerative disorders. View Full-Text
Keywords: MCU; neurodegenerative disorder; inflammation; iron overload; oxidative stress MCU; neurodegenerative disorder; inflammation; iron overload; oxidative stress
Show Figures

Graphical abstract

MDPI and ACS Style

Liao, Y.; Dong, Y.; Cheng, J. The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders. Int. J. Mol. Sci. 2017, 18, 248.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop