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Int. J. Mol. Sci. 2017, 18(2), 350;

AKT Axis, miR-21, and RECK Play Pivotal Roles in Dihydroartemisinin Killing Malignant Glioma Cells

Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, China
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China
Author to whom correspondence should be addressed.
Academic Editor: Ge Zhang
Received: 8 November 2016 / Revised: 4 January 2017 / Accepted: 31 January 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Translational Molecular Medicine & Molecular Drug Discovery)
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Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, is known to play important roles in inhibiting proliferation rate, inducing apoptosis, as well as hindering the metastasis and invasion of glioma cells, but the underlying mechanisms are still unclear so far. In this study, methyl thiazolyl tetrazolium (MTT), colony-forming, wound healing, invasion, and apoptosis assays were performed to investigate the effect of DHA on malignant glioma cells. Results showed that DHA induced apoptosis of malignant glioma cells through Protein Kinase B (AKT) axis, induced death of malignant glioma cells by downregulating miR-21, and inhibited the invasion of malignant glioma cells corresponding with up-regulation of the reversion-inducing-cysteine-rich protein with kazal motifs (RECK). These results revealed that AKT axis, miR-21, and RECK play pivotal roles in DHA killing malignant glioma cells, suggesting that DHA is a potential agent for treating glioma. View Full-Text
Keywords: dihydroartemisinin (DHA); glioma; miR-21; RECK; apoptosis; metastasis; invasion dihydroartemisinin (DHA); glioma; miR-21; RECK; apoptosis; metastasis; invasion

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Shao, Y.-Y.; Zhang, T.-L.; Wu, L.-X.; Zou, H.-C.; Li, S.; Huang, J.; Zhou, H.-H. AKT Axis, miR-21, and RECK Play Pivotal Roles in Dihydroartemisinin Killing Malignant Glioma Cells. Int. J. Mol. Sci. 2017, 18, 350.

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