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Int. J. Mol. Sci. 2017, 18(12), 2562; https://doi.org/10.3390/ijms18122562

Bioaccumulation and Toxicity of Carbon Nanoparticles Suspension Injection in Intravenously Exposed Mice

1
State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610041, China
2
College of Chemistry & Environment Protection Engineering, Southwest Minzu University, Chengdu 610041, China
3
Chongqing Lummy Pharmaceutical Co., Ltd., Chongqing 401123, China
*
Authors to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 21 November 2017 / Accepted: 23 November 2017 / Published: 29 November 2017
(This article belongs to the Collection Bioactive Nanoparticles)
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Abstract

Carbon nanoparticles suspension injection (CNSI) has been widely used in tumor drainage lymph node mapping, and its new applications in drug delivery, photothermal therapy, and so on have been extensively investigated. To develop new clinical applications, the toxicity of CNSI after intravenous exposure should be thoroughly investigated to ensure its safe use. Herein, we studied the bioaccumulation of CNSI in reticuloendothelial system (RES) organs and the corresponding toxicity to mice. After the intravenous injection of CNSI, no abnormal behavior of mice was observed during the 28-day observation period. The body weight increases were similar among the exposed groups and the control group. The parameters of hematology and serum biochemistry remained nearly unchanged, with very few of them showing significant changes. The low toxicity of CNSI was also reflected by the unchanged histopathological characteristics of these organs. The injection of CNSI did not induce higher apoptosis levels either. The slight oxidative stress was observed in RES organs at high dosages at day 7 post-exposure. The implication to the clinical applications and toxicological evaluations of carbon nanomaterials is discussed. View Full-Text
Keywords: carbon nanoparticles suspension injection; biodistribution; biosafety; Raman spectroscopy; nanotoxicity carbon nanoparticles suspension injection; biodistribution; biosafety; Raman spectroscopy; nanotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Xie, P.; Yang, S.-T.; He, T.; Yang, S.; Tang, X.-H. Bioaccumulation and Toxicity of Carbon Nanoparticles Suspension Injection in Intravenously Exposed Mice. Int. J. Mol. Sci. 2017, 18, 2562.

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