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KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation

Vascular Biology and Stem Cell Research Laboratory, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(11), 2383; https://doi.org/10.3390/ijms18112383
Received: 23 September 2017 / Revised: 17 October 2017 / Accepted: 8 November 2017 / Published: 10 November 2017
(This article belongs to the Special Issue NF-κB and Cancer)
KLF2 (Kruppel-like factor 2) is a member of the zinc finger transcription factor family, which critically regulates embryonic lung development, function of endothelial cells and maintenance of quiescence in T-cells and monocytes. It is expressed in naïve T-cells and monocytes, however its level of expression decreases during activation and differentiation. KLF2 also plays critical regulatory role in various inflammatory diseases and their pathogenesis. Nuclear factor-kappaB (NF-κB) is an important inducer of inflammation and the inflammation is mediated through the transcription of several proinflammatory cytokines, chemokines and adhesion molecules. So, both transcriptional factors KLF2 and NF-κB are being associated with the similar cellular functions and their maintenance. It was shown that KLF2 regulates most of the NF-κB-mediated activities. In this review, we focused on emphasizing the involvement of KLF2 in health and disease states and how they interact with transcriptional master regulator NF-κB. View Full-Text
Keywords: KLF2; NF-κB; immune cells; inflammation and diseases KLF2; NF-κB; immune cells; inflammation and diseases
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Jha, P.; Das, H. KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation. Int. J. Mol. Sci. 2017, 18, 2383.

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