Next Article in Journal
Macrophage Migration Inhibitory Factor Predicts Outcome in Complex Aortic Surgery
Next Article in Special Issue
Impact of Labile Zinc on Heart Function: From Physiology to Pathophysiology
Previous Article in Journal
A Comprehensive Study on Pyrolysis Mechanism of Substituted β-O-4 Type Lignin Dimers
Previous Article in Special Issue
Dietary Zinc Acts as a Sleep Modulator
Open AccessReview

Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis

Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA
Texas Biomedical Research Institute, San Antonio, TX 78227, USA
Center for Pharmacogenomics, Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43085, USA
College of Pharmacy, The University of Nebraska Medical Center, Omaha, NE 68198-6120, USA
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(11), 2375;
Received: 6 October 2017 / Revised: 1 November 2017 / Accepted: 6 November 2017 / Published: 9 November 2017
(This article belongs to the Special Issue Zinc Signaling in Physiology and Pathogenesis)
Tuberculosis (TB) is a global epidemic caused by the infection of human macrophages with the world’s most deadly single bacterial pathogen, Mycobacterium tuberculosis (M.tb). M.tb resides in a phagosomal niche within macrophages, where trace element concentrations impact the immune response, bacterial metal metabolism, and bacterial survival. The manipulation of micronutrients is a critical mechanism of host defense against infection. In particular, the human zinc transporter Zrt-/Irt-like protein 8 (ZIP8), one of 14 ZIP family members, is important in the flux of divalent cations, including zinc, into the cytoplasm of macrophages. It also has been observed to exist on the membrane of cellular organelles, where it can serve as an efflux pump that transports zinc into the cytosol. ZIP8 is highly inducible in response to M.tb infection of macrophages, and we have observed its localization to the M.tb phagosome. The expression, localization, and function of ZIP8 and other divalent cation transporters within macrophages have important implications for TB prevention and dissemination and warrant further study. In particular, given the importance of zinc as an essential nutrient required for humans and M.tb, it is not yet clear whether ZIP-guided zinc transport serves as a host protective factor or, rather, is targeted by M.tb to enable its phagosomal survival. View Full-Text
Keywords: zinc; zinc transporter; tuberculosis; lung; macrophage; innate immunity zinc; zinc transporter; tuberculosis; lung; macrophage; innate immunity
Show Figures

Graphical abstract

MDPI and ACS Style

Pyle, C.J.; Azad, A.K.; Papp, A.C.; Sadee, W.; Knoell, D.L.; Schlesinger, L.S. Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis. Int. J. Mol. Sci. 2017, 18, 2375.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop