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Zinc in Cellular Regulation: The Nature and Significance of “Zinc Signals”
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Dietary Zinc Acts as a Sleep Modulator

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 305-8575 Tsukuba, Japan
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Int. J. Mol. Sci. 2017, 18(11), 2334; https://doi.org/10.3390/ijms18112334
Received: 3 October 2017 / Revised: 2 November 2017 / Accepted: 2 November 2017 / Published: 5 November 2017
(This article belongs to the Special Issue Zinc Signaling in Physiology and Pathogenesis)
While zinc is known to be important for many biological processes in animals at a molecular and physiological level, new evidence indicates that it may also be involved in the regulation of sleep. Recent research has concluded that zinc serum concentration varies with the amount of sleep, while orally administered zinc increases the amount and the quality of sleep in mice and humans. In this review, we provide an exhaustive study of the literature connecting zinc and sleep, and try to evaluate which molecular mechanism is likely to be involved in this phenomenon. A better understanding should provide critical information not only about the way zinc is related to sleep but also about how sleep itself works and what its real function is. View Full-Text
Keywords: sleep; zinc; nutrition; brain; randomized controlled trial sleep; zinc; nutrition; brain; randomized controlled trial
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Cherasse, Y.; Urade, Y. Dietary Zinc Acts as a Sleep Modulator. Int. J. Mol. Sci. 2017, 18, 2334.

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