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Article

Influence of Preoperative Serum Aspartate Aminotransferase (AST) Level on the Prognosis of Patients with Non-Small Cell Lung Cancer

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
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Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Int. J. Mol. Sci. 2016, 17(9), 1474; https://doi.org/10.3390/ijms17091474
Received: 24 June 2016 / Revised: 9 August 2016 / Accepted: 29 August 2016 / Published: 3 September 2016
The purpose of this work is to analyze preoperative serum aspartate aminotransferase (AST) levels and their effect on the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical operation. These analyses were performed retrospectively in patients with NSCLC followed by surgery; participants were recruited between January 2004 and January 2008. All clinical information and laboratory results were collected from medical records. We explored the association between preoperative serum AST and recurrence-free survival (RFS), and the overall survival (OS) of NSCLC patients. Kaplan–Meier analysis and Cox multivariate analysis, stratified by the AST median value, were used to evaluate the prognostic effect. A chi-squared test was performed to compare clinical characteristics in different subgroups. A p-value of ≤0.05 was considered to be statistically significant. A total of 231 patients were enrolled. The median RFS and OS were 22 and 59 months, respectively. The AST levels were divided into two groups, using a cut-off value of 19 U/L: High AST (>19 U/L), n = 113 vs. low AST (≤19 U/L), n = 118. Multivariate analysis indicated that preoperative serum AST > 19 U/L (hazard ratio (HR) = 0.685, 95% confidence interval (CI): 0.493–0.994, p = 0.046 for RFS, HR = 0.646, 95% CI: 0.438–0.954, p = 0.028 for OS) was an independent prognostic factor for both RFS and OS. High preoperative serum AST levels may serve as a valuable marker to predict the prognosis of NSCLC after operation. View Full-Text
Keywords: aspartate aminotransferase (AST); recurrence-free survival (RFS); overall survival (OS); prognosis; non-small cell lung cancer (NSCLC) aspartate aminotransferase (AST); recurrence-free survival (RFS); overall survival (OS); prognosis; non-small cell lung cancer (NSCLC)
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MDPI and ACS Style

Chen, S.-L.; Xue, N.; Wu, M.-T.; Chen, H.; He, X.; Li, J.-P.; Liu, W.-L.; Dai, S.-Q. Influence of Preoperative Serum Aspartate Aminotransferase (AST) Level on the Prognosis of Patients with Non-Small Cell Lung Cancer. Int. J. Mol. Sci. 2016, 17, 1474. https://doi.org/10.3390/ijms17091474

AMA Style

Chen S-L, Xue N, Wu M-T, Chen H, He X, Li J-P, Liu W-L, Dai S-Q. Influence of Preoperative Serum Aspartate Aminotransferase (AST) Level on the Prognosis of Patients with Non-Small Cell Lung Cancer. International Journal of Molecular Sciences. 2016; 17(9):1474. https://doi.org/10.3390/ijms17091474

Chicago/Turabian Style

Chen, Shu-Lin, Ning Xue, Mian-Tao Wu, Hao Chen, Xia He, Jian-Pei Li, Wan-Li Liu, and Shu-Qin Dai. 2016. "Influence of Preoperative Serum Aspartate Aminotransferase (AST) Level on the Prognosis of Patients with Non-Small Cell Lung Cancer" International Journal of Molecular Sciences 17, no. 9: 1474. https://doi.org/10.3390/ijms17091474

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