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Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi

Plant Breeding Institute Cobbitty, The University of Sydney, Private Bag 4011, Narellan, NSW 2567, Australia
La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia
Departamento de Genética, Campus de Excelencia Internacional Agroalimentario ceiA3, Universidad de Córdoba, Córdoba 14071, Spain
Department of Animal, Plant and Soil Sciences, AgriBio, La Trobe University, Bundoora, VIC 3083, Australia
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Int. J. Mol. Sci. 2016, 17(9), 1473;
Received: 4 August 2016 / Revised: 4 August 2016 / Accepted: 25 August 2016 / Published: 3 September 2016
(This article belongs to the Section Molecular Plant Sciences)
PDF [4592 KB, uploaded 3 September 2016]


Nicotiana alata defensins 1 and 2 (NaD1 and NaD2) are plant defensins from the ornamental tobacco that have antifungal activity against a variety of fungal pathogens. Some plant defensins interact with fungal cell wall O-glycosylated proteins. Therefore, we investigated if this was the case for NaD1 and NaD2, by assessing the sensitivity of the three Aspergillus nidulans (An) O-mannosyltransferase (pmt) knockout (KO) mutants (AnpmtA, AnpmtB, and AnpmtC). AnpmtA was resistant to both defensins, while AnpmtC was resistant to NaD2 only, suggesting NaD1 and NaD2 are unlikely to have a general interaction with O-linked side chains. Further evidence of this difference in the antifungal mechanism was provided by the dissimilarity of the NaD1 and NaD2 sensitivities of the Fusarium oxysporum f. sp. lycopersici (Fol) signalling knockout mutants from the cell wall integrity (CWI) and high osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathways. HOG pathway mutants were sensitive to both NaD1 and NaD2, while CWI pathway mutants only displayed sensitivity to NaD2. View Full-Text
Keywords: antifungal defensins; NaD1 and NaD2; CWI signalling pathway; HOG signalling pathway antifungal defensins; NaD1 and NaD2; CWI signalling pathway; HOG signalling pathway

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Dracatos, P.M.; Payne, J.; Di Pietro, A.; Anderson, M.A.; Plummer, K.M. Plant Defensins NaD1 and NaD2 Induce Different Stress Response Pathways in Fungi. Int. J. Mol. Sci. 2016, 17, 1473.

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