Next Article in Journal
Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease
Next Article in Special Issue
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells
Previous Article in Journal
Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C
Previous Article in Special Issue
Anti-Atherosclerotic Effects of a Phytoestrogen-Rich Herbal Preparation in Postmenopausal Women
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 17
Issue 9
10.3390/ijms17091382
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke

by
Slaven Pikija
1,
Jozef Magdic
2,
Anita Lukic
3,
Catharina Schreiber
4,
Johannes Sebastian Mutzenbach
1,
Mark R. McCoy
5 and
Johann Sellner
1,6,*
1
Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg 5020, Austria
2
Department of Neurology, Univerzitetni Klinični Center, Maribor 2000, Slovenia
3
Department of Anesthesiology, General Hospital Varazdin, Varazdin 42000, Croatia
4
Department of Cardiac Surgery, Salzburger Landeskliniken, Paracelsus Medical University, Salzburg 5020, Austria
5
Division of Neuroradiology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg 5020, Austria
6
Department of Neurology, Klinikum rechts der Isar, Technische Universität München, München 81675, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2016, 17(9), 1382; https://doi.org/10.3390/ijms17091382
Submission received: 24 July 2016 / Revised: 16 August 2016 / Accepted: 18 August 2016 / Published: 23 August 2016
(This article belongs to the Special Issue Vascular Biology and Therapeutics)
Browse Figures
Versions Notes

Abstract

We explored whether clot density in middle cerebral artery (MCA) occlusion is related to clinical variables, stroke etiology, blood constituents, and prestroke medication. We performed a retrospective chart review of patients with acute ischemic stroke of the anterior circulation admitted to two Central European stroke centers. The acquisition of non-contrast enhanced CT (NECT) and CT angiography (CTA) within 4.5 h of symptom onset was obligatory. We assessed the site of MCA occlusion as well as density, area, and length of the clot in 150 patients. The Hounsfield unit values for the clot were divided with contralateral MCA segment to yield relative Hounsfield Unit ratio (rHU). The site of the vessel occlusion (M1 vs. M2) and antiplatelet usage, but not stroke etiology, significantly influenced rHU. We found an inverse correlation of rHU with erythrocyte count (p < 0.001). The multivariate analysis revealed that a higher rHU (i.e., clot being more hyperdense) was more likely with the use of antiplatelets (OR 4.24, CI 1.10–16.31, p = 0.036). Erythrocyte (OR 0.18, CI 0.05–0.55, p = 0.003), and thrombocyte counts (OR 0.99, CI 0.98–0.99, p = 0.029) were associated with odds for more hypodense clots (lower rHU). Our study disclosed that antiplatelet therapy impacts the composition of intracranial clots of the anterior circulation.
Keywords: ischemic stroke; hyperdense artery sign; antiplatelets; computed tomography; clot ischemic stroke; hyperdense artery sign; antiplatelets; computed tomography; clot

Share and Cite

MDPI and ACS Style

Pikija, S.; Magdic, J.; Lukic, A.; Schreiber, C.; Mutzenbach, J.S.; McCoy, M.R.; Sellner, J. Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke. Int. J. Mol. Sci. 2016, 17, 1382. https://doi.org/10.3390/ijms17091382

AMA Style

Pikija S, Magdic J, Lukic A, Schreiber C, Mutzenbach JS, McCoy MR, Sellner J. Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke. International Journal of Molecular Sciences. 2016; 17(9):1382. https://doi.org/10.3390/ijms17091382

Chicago/Turabian Style

Pikija, Slaven, Jozef Magdic, Anita Lukic, Catharina Schreiber, Johannes Sebastian Mutzenbach, Mark R. McCoy, and Johann Sellner. 2016. "Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke" International Journal of Molecular Sciences 17, no. 9: 1382. https://doi.org/10.3390/ijms17091382

APA Style

Pikija, S., Magdic, J., Lukic, A., Schreiber, C., Mutzenbach, J. S., McCoy, M. R., & Sellner, J. (2016). Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke. International Journal of Molecular Sciences, 17(9), 1382. https://doi.org/10.3390/ijms17091382

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop