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Int. J. Mol. Sci. 2016, 17(9), 1379;

Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease

Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 26 July 2016 / Revised: 12 August 2016 / Accepted: 17 August 2016 / Published: 23 August 2016
(This article belongs to the Special Issue Macro- and Micro-nutrient Antioxidants)
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Nonalcoholic fatty liver disease (NAFLD) is one of the most important chronic liver diseases worldwide and has garnered increasing attention in recent decades. NAFLD is characterized by a wide range of liver changes, from simple steatosis to nonalcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. The blurred pathogenesis of NAFLD is very complicated and involves lipid accumulation, insulin resistance, inflammation, and fibrogenesis. NAFLD is closely associated with complications such as obesity, diabetes, steatohepatitis, and liver fibrosis. During the progression of NAFLD, reactive oxygen species (ROS) are activated and induce oxidative stress. Recent attempts at establishing effective NAFLD therapy have identified potential micronutrient antioxidants that may reduce the accumulation of ROS and finally ameliorate the disease. In this review, we present the molecular mechanisms involved in the pathogenesis of NAFLD and introduce some dietary antioxidants that may be used to prevent or cure NAFLD, such as vitamin D, E, and astaxanthin. View Full-Text
Keywords: nonalcoholic fatty liver disease (NAFLD); nonalcoholic steatohepatitis (NASH); antioxidants; insulin resistance; inflammation; fibrosis; vitamin D; vitamin E; astaxanthin nonalcoholic fatty liver disease (NAFLD); nonalcoholic steatohepatitis (NASH); antioxidants; insulin resistance; inflammation; fibrosis; vitamin D; vitamin E; astaxanthin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, G.; Ni, Y.; Nagata, N.; Xu, L.; Ota, T. Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2016, 17, 1379.

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