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Open AccessArticle

Effects of Hormone Therapy on Oxidative Stress in Postmenopausal Women with Metabolic Syndrome

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Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Guelatao No. 66, Col. Ejército de Oriente, Ciudad de México, México CP 09230, Mexico
2
División de Ginecología y Obstetricia, Hospital General Dr. Gustavo Baz Prada, Instituto de Salud del Estado de México, Av. Bordo de Xochiaca esq. Adolfo López Mateos S/N, Col. Tamaulipas, Nezahualcóyotl, Estado de México, México CP 57300, Mexico
*
Author to whom correspondence should be addressed.
Academic Editors: Maurizio Battino and Esra Capanoglu
Int. J. Mol. Sci. 2016, 17(9), 1388; https://doi.org/10.3390/ijms17091388
Received: 17 July 2016 / Revised: 11 August 2016 / Accepted: 16 August 2016 / Published: 24 August 2016
(This article belongs to the Special Issue Macro- and Micro-nutrient Antioxidants)
The aim of this study was to determine the effect of oral hormone therapy (HT) on oxidative stress (OS) in postmenopausal women with metabolic syndrome (MetS). A randomized, double blind, placebo-controlled trial was carried out. We formed four groups of 25 women each; healthy (HW) and MetS women (MSW) were assigned to HT (1 mg/day of estradiol valerate plus 5 mg/10 day of medroxiprogesterone) or placebo. We measured plasma lipoperoxides, erythrocyte superoxide dismutase and glutathione peroxidase, total plasma antioxidant status and uric acid, as OS markers. Alternative cut-off values of each parameter were defined and a stress score (SS) ranging from 0 to 7 was used as total OS. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) criteria. Participants were seen at baseline, 3 and 6 months. After 6 months, MetS decreased in MSW-HT (48%), their triglycerides and high-density lipoprotein cholesterol (HDL-c) improved; in the other groups no difference was found. SS in MSW-HT decreased (3.8 ± 0.3 to 1.7 ± 0.3, p < 0.05) and OS was also reduced (44%), this effect was evident since 3 mo. HW-HT with high OS also decreased (40%). In placebo groups there was no change. Our findings suggest that HT improve lipids and OS associated to MetS in postmenopausal women. View Full-Text
Keywords: oxidative stress; hormone therapy; postmenopause; metabolic syndrome; lipids profile oxidative stress; hormone therapy; postmenopause; metabolic syndrome; lipids profile
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MDPI and ACS Style

Sánchez-Rodríguez, M.A.; Zacarías-Flores, M.; Castrejón-Delgado, L.; Ruiz-Rodríguez, A.K.; Mendoza-Núñez, V.M. Effects of Hormone Therapy on Oxidative Stress in Postmenopausal Women with Metabolic Syndrome. Int. J. Mol. Sci. 2016, 17, 1388.

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