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Int. J. Mol. Sci. 2016, 17(8), 1107;

Antioxidant Activity of γ-Oryzanol: A Complex Network of Interactions

Department of Chemistry and Biochemistry, Institute of Bioscience, Sao Paulo State University, Botucatu 18618-689, Brazil
Department of Pathology, Botucatu Medical School, Sao Paulo State University, Botucatu 18618-970, Brazil
Author to whom correspondence should be addressed.
Academic Editors: Maurizio Battino and Esra Capanoglu
Received: 20 May 2016 / Revised: 29 June 2016 / Accepted: 7 July 2016 / Published: 9 August 2016
(This article belongs to the Special Issue Macro- and Micro-nutrient Antioxidants)
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γ-oryzanol (Orz), a steryl ferulate extracted from rice bran layer, exerts a wide spectrum of biological activities. In addition to its antioxidant activity, Orz is often associated with cholesterol-lowering, anti-inflammatory, anti-cancer and anti-diabetic effects. In recent years, the usefulness of Orz has been studied for the treatment of metabolic diseases, as it acts to ameliorate insulin activity, cholesterol metabolism, and associated chronic inflammation. Previous studies have shown the direct action of Orz when downregulating the expression of genes that encode proteins related to adiposity (CCAAT/enhancer binding proteins (C/EBPs)), inflammatory responses (nuclear factor kappa-B (NF-κB)), and metabolic syndrome (peroxisome proliferator-activated receptors (PPARs)). It is likely that this wide range of beneficial activities results from a complex network of interactions and signals triggered, and/or inhibited by its antioxidant properties. This review focuses on the significance of Orz in metabolic disorders, which feature remarkable oxidative imbalance, such as impaired glucose metabolism, obesity, and inflammation. View Full-Text
Keywords: γ-oryzanol; ferulic acid; antioxidant capacity; dyslipidemia; obesity; inflammation γ-oryzanol; ferulic acid; antioxidant capacity; dyslipidemia; obesity; inflammation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Minatel, I.O.; Francisqueti, F.V.; Corrêa, C.R.; Lima, G.P.P. Antioxidant Activity of γ-Oryzanol: A Complex Network of Interactions. Int. J. Mol. Sci. 2016, 17, 1107.

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