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Int. J. Mol. Sci. 2016, 17(5), 754;

MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis

Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona 60020, Italy
Mitochondria, Apoptosis and Cancer Research Group, School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, QLD 4222, Australia
Molecular Therapy Group, Institute of Biotechnology, Czech Academy of Sciences, Prague-West 25243, Czech Republic
Authors to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 31 March 2016 / Revised: 27 April 2016 / Accepted: 11 May 2016 / Published: 18 May 2016
(This article belongs to the Special Issue MicroRNA Regulation)
Full-Text   |   PDF [616 KB, uploaded 18 May 2016]   |  


The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance. View Full-Text
Keywords: miRNAs; metabolic reprogramming; tumorigenesis; miR-126 and cancer-stroma environment; miRNA regulating signaling pathways miRNAs; metabolic reprogramming; tumorigenesis; miR-126 and cancer-stroma environment; miRNA regulating signaling pathways

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Tomasetti, M.; Amati, M.; Santarelli, L.; Neuzil, J. MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis. Int. J. Mol. Sci. 2016, 17, 754.

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