Next Article in Journal
RVMAB: Using the Relevance Vector Machine Model Combined with Average Blocks to Predict the Interactions of Proteins from Protein Sequences
Next Article in Special Issue
MicroRNA-19b Downregulates Gap Junction Protein Alpha1 and Synergizes with MicroRNA-1 in Viral Myocarditis
Previous Article in Journal
Differential MicroRNA Expression Profile in Myxomatous Mitral Valve Prolapse and Fibroelastic Deficiency Valves
Previous Article in Special Issue
Managing Pancreatic Adenocarcinoma: A Special Focus in MicroRNA Gene Therapy
Review

MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis

1
Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona 60020, Italy
2
Mitochondria, Apoptosis and Cancer Research Group, School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, QLD 4222, Australia
3
Molecular Therapy Group, Institute of Biotechnology, Czech Academy of Sciences, Prague-West 25243, Czech Republic
*
Authors to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Int. J. Mol. Sci. 2016, 17(5), 754; https://doi.org/10.3390/ijms17050754
Received: 31 March 2016 / Revised: 27 April 2016 / Accepted: 11 May 2016 / Published: 18 May 2016
(This article belongs to the Special Issue MicroRNA Regulation)
The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance. View Full-Text
Keywords: miRNAs; metabolic reprogramming; tumorigenesis; miR-126 and cancer-stroma environment; miRNA regulating signaling pathways miRNAs; metabolic reprogramming; tumorigenesis; miR-126 and cancer-stroma environment; miRNA regulating signaling pathways
Show Figures

Graphical abstract

MDPI and ACS Style

Tomasetti, M.; Amati, M.; Santarelli, L.; Neuzil, J. MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis. Int. J. Mol. Sci. 2016, 17, 754. https://doi.org/10.3390/ijms17050754

AMA Style

Tomasetti M, Amati M, Santarelli L, Neuzil J. MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis. International Journal of Molecular Sciences. 2016; 17(5):754. https://doi.org/10.3390/ijms17050754

Chicago/Turabian Style

Tomasetti, Marco, Monica Amati, Lory Santarelli, and Jiri Neuzil. 2016. "MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis" International Journal of Molecular Sciences 17, no. 5: 754. https://doi.org/10.3390/ijms17050754

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop