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Int. J. Mol. Sci. 2016, 17(5), 680;

Legume NADPH Oxidases Have Crucial Roles at Different Stages of Nodulation

Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, 6726 Szeged, Hungary
Escuela Nacional de Estudios Superiores, Universidad Nacional Autónoma de México (UNAM), León, Blvd. UNAM 2011, León 37684, Guanajuato, Mexico
Departamento de Biología Molecular de Plantas, Instituto de Biotecnología, Universidad Nacional Autónoma de México, UNAM, Apartado Postal 510-3, Cuernavaca 62271, Morelos, Mexico
This article is dedicated to my beloved husband Federico Sánchez PhD, who passed away on 4 April 2016
Author to whom correspondence should be addressed.
Academic Editors: Peter M. Gresshoff and Brett Ferguson
Received: 13 March 2016 / Revised: 20 April 2016 / Accepted: 27 April 2016 / Published: 18 May 2016
(This article belongs to the Special Issue Molecular Signals in Nodulation Control)
Full-Text   |   PDF [4794 KB, uploaded 18 May 2016]   |  


Plant NADPH oxidases, formerly known as respiratory burst oxidase homologues (RBOHs), are plasma membrane enzymes dedicated to reactive oxygen species (ROS) production. These oxidases are implicated in a wide variety of processes, ranging from tissue and organ growth and development to signaling pathways in response to abiotic and biotic stimuli. Research on the roles of RBOHs in the plant’s response to biotic stresses has mainly focused on plant-pathogen interactions; nonetheless, recent findings have shown that these oxidases are also involved in the legume-rhizobia symbiosis. The legume-rhizobia symbiosis leads to the formation of the root nodule, where rhizobia reduce atmospheric nitrogen to ammonia. A complex signaling and developmental pathway in the legume root hair and root facilitate rhizobial entrance and nodule organogenesis, respectively. Interestingly, several reports demonstrate that RBOH-mediated ROS production displays versatile roles at different stages of nodulation. The evidence collected to date indicates that ROS act as signaling molecules that regulate rhizobial invasion and also function in nodule senescence. This review summarizes discoveries that support the key and versatile roles of various RBOH members in the legume-rhizobia symbiosis. View Full-Text
Keywords: legumes; RBOH; reactive oxygen species (ROS); rhizobia; symbiosis legumes; RBOH; reactive oxygen species (ROS); rhizobia; symbiosis

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Montiel, J.; Arthikala, M.-K.; Cárdenas, L.; Quinto, C. Legume NADPH Oxidases Have Crucial Roles at Different Stages of Nodulation. Int. J. Mol. Sci. 2016, 17, 680.

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