Next Article in Journal
Challenging Density Functional Theory Calculations with Hemes and Porphyrins
Next Article in Special Issue
The Role of Galectin-3 in the Kidneys
Previous Article in Journal
Interleukin-17A Differentially Induces Inflammatory and Metabolic Gene Expression in the Adipose Tissues of Lean and Obese Mice
Previous Article in Special Issue
The Role of Sialyl-Tn in Cancer
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 17
Issue 4
10.3390/ijms17040523
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR)

by
Stefan Hutter
1,
Julia Knabl
1,
Ulrich Andergassen
1,
Simone Hofmann
1,
Christina Kuhn
1,
Sven Mahner
1,
Petra Arck
2 and
Udo Jeschke
1,*
1
Department of Gynecology and Obstetrics, Ludwig Maximilians University of Munich, Maistraße 11, 80337 Munich, Germany
2
Department of Gynecology and Obstetrics, University of Hamburg, Martinistr. 52, 20246 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2016, 17(4), 523; https://doi.org/10.3390/ijms17040523
Submission received: 18 January 2016 / Revised: 18 March 2016 / Accepted: 22 March 2016 / Published: 7 April 2016
(This article belongs to the Special Issue Glycan–Receptor Interaction)
Browse Figures
Versions Notes

Abstract

Galectins (gal) are members of the mammalian β-galactoside-binding proteins and recognize Galβ1-4GlcNAc and Galβ1-4GalNac (Thomsen-Friedenreich antigen (TF)) sequences of several cell surface oligosaccharides. In this study, gal-1, -2, -3 and -13 were investigated systematically in the trophoblast and decidua compartment of intrauterine growth restriction (IUGR) placentas and normal third trimester control placentas and stratified by fetal gender and gestational age. Within this study, 29 third trimester placentas after delivery were analyzed. Fetal gender was equally divided within both groups, and immunohistochemical staining was analyzed according to fetal gender and gestational age. Double immune-fluorescence with trophoblast-specific markers was used to identify galectin-expressing cells at the feto-maternal interface in the decidua. Gal-3 was significantly downregulated only in the extravillous trophoblast of IUGR placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas. In addition, gal-2 and gal-13 showed a highly correlated expression scheme in the placenta. There are significant gender-specific expression patterns for single prototype galectins with downregulation of gal-2 and gal-13 of male gender placentas in cases of IUGR. Gal-3 as the chimera type galectin shows only little gender-specific differences in expression, which disappear in IUGR cases.
Keywords: galectins; placenta; trophoblast; decidua; IUGR galectins; placenta; trophoblast; decidua; IUGR
Graphical Abstract

Share and Cite

MDPI and ACS Style

Hutter, S.; Knabl, J.; Andergassen, U.; Hofmann, S.; Kuhn, C.; Mahner, S.; Arck, P.; Jeschke, U. Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR). Int. J. Mol. Sci. 2016, 17, 523. https://doi.org/10.3390/ijms17040523

AMA Style

Hutter S, Knabl J, Andergassen U, Hofmann S, Kuhn C, Mahner S, Arck P, Jeschke U. Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR). International Journal of Molecular Sciences. 2016; 17(4):523. https://doi.org/10.3390/ijms17040523

Chicago/Turabian Style

Hutter, Stefan, Julia Knabl, Ulrich Andergassen, Simone Hofmann, Christina Kuhn, Sven Mahner, Petra Arck, and Udo Jeschke. 2016. "Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR)" International Journal of Molecular Sciences 17, no. 4: 523. https://doi.org/10.3390/ijms17040523

APA Style

Hutter, S., Knabl, J., Andergassen, U., Hofmann, S., Kuhn, C., Mahner, S., Arck, P., & Jeschke, U. (2016). Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR). International Journal of Molecular Sciences, 17(4), 523. https://doi.org/10.3390/ijms17040523

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop