Next Article in Journal
MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma
Next Article in Special Issue
Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR)
Previous Article in Journal
Integrative Analyses of miRNA-mRNA Interactions Reveal let-7b, miR-128 and MAPK Pathway Involvement in Muscle Mass Loss in Sex-Linked Dwarf Chickens
Review

The Role of Sialyl-Tn in Cancer

Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne NE1 3BZ, UK
Academic Editor: Cheorl-Ho Kim
Int. J. Mol. Sci. 2016, 17(3), 275; https://doi.org/10.3390/ijms17030275
Received: 5 February 2016 / Revised: 17 February 2016 / Accepted: 18 February 2016 / Published: 24 February 2016
(This article belongs to the Special Issue Glycan–Receptor Interaction)
Activation of an aberrant glycosylation pathway in cancer cells can lead to expression of the onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid α-2,6 linked to GalNAc α-O-Ser/Thr and is associated with an adverse outcome and poor prognosis in cancer patients. The biosynthesis of the sTn antigen has been linked to the expression of the sialytransferase ST6GalNAc1, and also to mutations in and loss of heterozygosity of the COSMC gene. sTn neo- or over-expression occurs in many types of epithelial cancer including gastric, colon, breast, lung, oesophageal, prostate and endometrial cancer. sTn is believed to be carried by a variety of glycoproteins and may influence protein function and be involved in tumour development. This review discusses how the role of sTn in cancer development and tumour cell invasiveness might be organ specific and occur through different mechanisms depending on each cancer type or subtype. As the sTn-antigen is expressed early in carcinogenesis targeting sTn in cancer may enable the targeting of tumours from the earliest stage. View Full-Text
Keywords: sialyl-Tn; cancer; O-glycans; ST6GalNAc1; COSMC; glycosylation sialyl-Tn; cancer; O-glycans; ST6GalNAc1; COSMC; glycosylation
Show Figures

Figure 1

MDPI and ACS Style

Munkley, J. The Role of Sialyl-Tn in Cancer. Int. J. Mol. Sci. 2016, 17, 275. https://doi.org/10.3390/ijms17030275

AMA Style

Munkley J. The Role of Sialyl-Tn in Cancer. International Journal of Molecular Sciences. 2016; 17(3):275. https://doi.org/10.3390/ijms17030275

Chicago/Turabian Style

Munkley, Jennifer. 2016. "The Role of Sialyl-Tn in Cancer" Int. J. Mol. Sci. 17, no. 3: 275. https://doi.org/10.3390/ijms17030275

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop