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Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases

by Meng Li 1, Ping Gao 2 and Junping Zhang 3,*
1
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2
Department of Medical Imaging, Urumqi General Hospital of Lanzhou Military Area Command, Urumqi 830000, China
3
Department of cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medcine, Tianjin 300192, China
*
Author to whom correspondence should be addressed.
Academic Editor: H. W. M. Niessen
Int. J. Mol. Sci. 2016, 17(3), 332; https://doi.org/10.3390/ijms17030332
Received: 12 December 2015 / Revised: 6 February 2016 / Accepted: 19 February 2016 / Published: 3 March 2016
(This article belongs to the Section Biochemistry)
Autophagy is a cell survival process which is related to breaking down and reusing cytoplasm components. Moreover, autophagy regulates cell death under certain conditions. Apoptosis has the characteristics of chromatin agglutination and the shrinking of nuclear and apoptosis body form. Even if the mechanisms of autophagy and apoptosis have differences, some proteins modulate both autophagy and apoptosis. Crosstalk between them exists. This review highlights recent advances in the interaction of autophagy and apoptosis and its importance in the development of cardiovascular diseases. View Full-Text
Keywords: autophagy; apoptosis; crosstalk; cardiovascular diseases autophagy; apoptosis; crosstalk; cardiovascular diseases
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Li, M.; Gao, P.; Zhang, J. Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases. Int. J. Mol. Sci. 2016, 17, 332.

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