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Mycobacterium tuberculosis: Manipulator of Protective Immunity

Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Howard College Campus, King George V Avenue, 4001 Durban, South Africa
Author to whom correspondence should be addressed.
Current address: Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Academic Editor: Susanna Esposito
Int. J. Mol. Sci. 2016, 17(3), 131;
Received: 17 November 2015 / Revised: 17 December 2015 / Accepted: 23 December 2015 / Published: 25 February 2016
Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes sufficient immunopathology to facilitate its transmission. This review highlights MTB as the driver of disease pathogenesis and presents evidence of the mechanisms by which MTB manipulates the protective immune response into a pathological productive infection. View Full-Text
Keywords: tuberculosis; mycobacterium; granuloma; foamy macrophage tuberculosis; mycobacterium; granuloma; foamy macrophage
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MDPI and ACS Style

Korb, V.C.; Chuturgoon, A.A.; Moodley, D. Mycobacterium tuberculosis: Manipulator of Protective Immunity. Int. J. Mol. Sci. 2016, 17, 131.

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