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Int. J. Mol. Sci. 2016, 17(3), 131;

Mycobacterium tuberculosis: Manipulator of Protective Immunity

Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Howard College Campus, King George V Avenue, 4001 Durban, South Africa
Current address: Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Author to whom correspondence should be addressed.
Academic Editor: Susanna Esposito
Received: 17 November 2015 / Revised: 17 December 2015 / Accepted: 23 December 2015 / Published: 25 February 2016
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Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes sufficient immunopathology to facilitate its transmission. This review highlights MTB as the driver of disease pathogenesis and presents evidence of the mechanisms by which MTB manipulates the protective immune response into a pathological productive infection. View Full-Text
Keywords: tuberculosis; mycobacterium; granuloma; foamy macrophage tuberculosis; mycobacterium; granuloma; foamy macrophage

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Korb, V.C.; Chuturgoon, A.A.; Moodley, D. Mycobacterium tuberculosis: Manipulator of Protective Immunity. Int. J. Mol. Sci. 2016, 17, 131.

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