Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells

Kim, Dong-Cheol; Yoon, Chi-Su; Quang, Tran Hong; Ko, Wonmin; Kim, Jong-Su; Oh, Hyuncheol; Kim, Youn-Chul

doi:10.3390/ijms17020255

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Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells

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Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570–749, Korea

Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, Vietnam

Author to whom correspondence should be addressed.

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These authors contributed equally to this study.

Academic Editor: Chang Won Choi

Int. J. Mol. Sci. 2016, 17(2), 255; https://doi.org/10.3390/ijms17020255

Received: 8 December 2015 / Revised: 12 January 2016 / Accepted: 5 February 2016 / Published: 19 February 2016

(This article belongs to the Special Issue Plant-Derived Pharmaceuticals by Molecular Farming 2016)

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Abstract

In Korea and China, Cudrania tricuspidata Bureau (Moraceae) is an important traditional medicinal plant used to treat lumbago, hemoptysis, and contusions. The C. tricuspidata methanol extract suppressed both production of NO and PGE₂ in BV2 microglial cells. Cudraflavanone D (1), isolated from this extract, remarkably suppressed the protein expression of inducible NO synthase and cyclooxygenase-2, and decreased the levels of NO and PGE₂ in BV2 microglial cells exposed to lipopolysaccharide. Cudraflavanone D (1) also decreased IL-6, TNF-α, IL-12, and IL-1β production, blocked nuclear translocation of NF-κB heterodimers (p50 and p65) by interrupting the degradation and phosphorylation of inhibitor of IκB-α, and inhibited NF-κB binding. In addition, cudraflavanone D (1) suppressed the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 MAPK pathways. This study indicated that cudraflavanone D (1) can be a potential drug candidate for the cure of neuroinflammation. View Full-Text

Keywords: Cudrania tricuspidata; cudraflavanone D; microglia; neuroinflammation; nuclear factor-κB; mitogen-activated protein kinase

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Kim, D.-C.; Yoon, C.-S.; Quang, T.H.; Ko, W.; Kim, J.-S.; Oh, H.; Kim, Y.-C. Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells. Int. J. Mol. Sci. 2016, 17, 255. https://doi.org/10.3390/ijms17020255

AMA Style

Kim D-C, Yoon C-S, Quang TH, Ko W, Kim J-S, Oh H, Kim Y-C. Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells. International Journal of Molecular Sciences. 2016; 17(2):255. https://doi.org/10.3390/ijms17020255

Chicago/Turabian Style

Kim, Dong-Cheol, Chi-Su Yoon, Tran H. Quang, Wonmin Ko, Jong-Su Kim, Hyuncheol Oh, and Youn-Chul Kim. 2016. "Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells" International Journal of Molecular Sciences 17, no. 2: 255. https://doi.org/10.3390/ijms17020255

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Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells

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