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Open AccessArticle

Hepatoprotective Effect of Cuscuta campestris Yunck. Whole Plant on Carbon Tetrachloride Induced Chronic Liver Injury in Mice

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, 500 Liufeng Rd., Wufeng, Taichung 41354, Taiwan
Department of Optometry, Jen-Teh Junior College of Medicine, Nursing and Management, 79-9 Sha-Luen Hu Xi-Zhou Li Hou-Loung Town, Miaoli 356, Taiwan
Graduate Institute of Biotechnology, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung 402, Taiwan
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Toshio Morikawa
Int. J. Mol. Sci. 2016, 17(12), 2056;
Received: 11 October 2016 / Revised: 24 November 2016 / Accepted: 1 December 2016 / Published: 7 December 2016
(This article belongs to the Special Issue Biological Activity of Natural Secondary Metabolite Products)
PDF [3791 KB, uploaded 7 December 2016]


Cuscuta seeds and whole plant have been used to nourish the liver and kidney. This study was aimed to investigate the hepatoprotective activity of the ethanol extract of Cuscuta campestris Yunck. whole plant (CCEtOH). The hepatoprotective effect of CCEtOH (20, 100 and 500 mg/kg) was evaluated on carbon tetrachloride (CCl4)-induced chronic liver injury. Serum alanine aminotransferase, aspartate aminotransferase, triglyceride and cholesterol were measured and the fibrosis was histologically examined. CCEtOH exhibited a significant inhibition of the increase of serum alanine aminotransferase, aspartate aminotransferase, triglyceride and cholesterol. Histological analyses showed that fibrosis of liver induced by CCl4 were significantly reduced by CCEtOH. In addition, 20, 100 and 500 mg/kg of the extract decreased the level of malondialdehyde (MDA) and enhanced the activities of anti-oxidative enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRd) in the liver. We demonstrate that the hepatoprotective mechanisms of CCEtOH were likely to be associated to the decrease in MDA level by increasing the activities of antioxidant enzymes such as SOD, GPx and GRd. In addition, our findings provide evidence that C. campestris Yunck. whole plant possesses a hepatoprotective activity to ameliorate chronic liver injury. View Full-Text
Keywords: Cuscuta campestris; hepatoprotective effect; carbon tetrachloride; fibrosis; antioxidant effect Cuscuta campestris; hepatoprotective effect; carbon tetrachloride; fibrosis; antioxidant effect

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Peng, W.-H.; Chen, Y.-W.; Lee, M.-S.; Chang, W.-T.; Tsai, J.-C.; Lin, Y.-C.; Lin, M.-K. Hepatoprotective Effect of Cuscuta campestris Yunck. Whole Plant on Carbon Tetrachloride Induced Chronic Liver Injury in Mice. Int. J. Mol. Sci. 2016, 17, 2056.

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