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Review

The Telomerase-Derived Anticancer Peptide Vaccine GV1001 as an Extracellular Heat Shock Protein-Mediated Cell-Penetrating Peptide

by 1,†, 2,†, 2 and 1,*
1
Department of Biomedical Sciences, Microbiology and Immunology, and Liver Research Institute, College of Medicine, Seoul National University, Seoul 03080, Korea
2
Department of Microbiology, Konkuk University School of Medicine, Seoul 05030, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Jagdish Singh and Buddhadev Layek
Int. J. Mol. Sci. 2016, 17(12), 2054; https://doi.org/10.3390/ijms17122054
Received: 7 November 2016 / Revised: 28 November 2016 / Accepted: 1 December 2016 / Published: 7 December 2016
(This article belongs to the Special Issue Cell-Penetrating Peptides 2016)
Cell-penetrating peptides (CPPs), which can facilitate the transport of molecular cargo across the plasma membrane, have become important tools in promoting the cellular delivery of macromolecules. GV1001, a peptide derived from a reverse-transcriptase subunit of telomerase (hTERT) and developed as a vaccine against various cancers, reportedly has unexpected CPP properties. Unlike typical CPPs, such as the HIV-1 TAT peptide, GV1001 enabled the cytosolic delivery of macromolecules such as proteins, DNA and siRNA via extracellular heat shock protein 90 (eHSP90) and 70 (eHSP70) complexes. The eHSP-GV1001 interaction may have biological effects in addition to its cytosolic delivery function. GV1001 was originally designed as a major histocompatibility complex (MHC) class II-binding cancer epitope, but its CPP properties may contribute to its strong anti-cancer immune response relative to other telomerase peptide-based vaccines. Cell signaling via eHSP-GV1001 binding may lead to unexpected biological effects, such as direct anticancer or antiviral effects. In this review, we focus on the CPP effects of GV1001 bound to eHSP90 and eHSP70. View Full-Text
Keywords: cell-penetrating peptides (CPPs); reverse-transcriptase-subunit of telomerase (hTERT); GV1001; heat shock protein 90 cell-penetrating peptides (CPPs); reverse-transcriptase-subunit of telomerase (hTERT); GV1001; heat shock protein 90
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MDPI and ACS Style

Kim, H.; Seo, E.-H.; Lee, S.-H.; Kim, B.-J. The Telomerase-Derived Anticancer Peptide Vaccine GV1001 as an Extracellular Heat Shock Protein-Mediated Cell-Penetrating Peptide. Int. J. Mol. Sci. 2016, 17, 2054. https://doi.org/10.3390/ijms17122054

AMA Style

Kim H, Seo E-H, Lee S-H, Kim B-J. The Telomerase-Derived Anticancer Peptide Vaccine GV1001 as an Extracellular Heat Shock Protein-Mediated Cell-Penetrating Peptide. International Journal of Molecular Sciences. 2016; 17(12):2054. https://doi.org/10.3390/ijms17122054

Chicago/Turabian Style

Kim, Hong, Eun-Hye Seo, Seung-Hyun Lee, and Bum-Joon Kim. 2016. "The Telomerase-Derived Anticancer Peptide Vaccine GV1001 as an Extracellular Heat Shock Protein-Mediated Cell-Penetrating Peptide" International Journal of Molecular Sciences 17, no. 12: 2054. https://doi.org/10.3390/ijms17122054

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