Role of Osteogenic Growth Peptide (OGP) and OGP(10–14) in Bone Regeneration: A Review

Pigossi, Suzane C.; Medeiros, Marcell C.; Saska, Sybele; Cirelli, Joni A.; Scarel-Caminaga, Raquel M.

doi:10.3390/ijms17111885

Open AccessReview

Role of Osteogenic Growth Peptide (OGP) and OGP(10–14) in Bone Regeneration: A Review

by

Suzane C. Pigossi

^1,2

,

Marcell C. Medeiros

¹

,

Sybele Saska

³,

Joni A. Cirelli

¹

and

Raquel M. Scarel-Caminaga

^1,2,*

¹

Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP–São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil

²

Department of Morphology, School of Dentistry, UNESP– São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil

³

Department of General and Inorganic Chemistry, Institute of Chemistry, UNESP–São Paulo State University, Professor Francisco Degni St, 55, CEP 14800-900 Araraquara, São Paulo, Brazil

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2016, 17(11), 1885; https://doi.org/10.3390/ijms17111885

Submission received: 14 September 2016 / Revised: 24 October 2016 / Accepted: 2 November 2016 / Published: 22 November 2016

(This article belongs to the Special Issue Advances in Bone and Cartilage Research)

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Abstract

Bone regeneration is a process that involves several molecular mediators, such as growth factors, which directly affect the proliferation, migration and differentiation of bone-related cells. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10–14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells. However, the exact molecular mechanisms that promote osteoblastic proliferation and differentiation are not completely understood. This review presents the main chemical characteristics of OGP and/or OGP(10–14), and also discusses the potential molecular pathways induced by these growth factors to promote proliferation and differentiation of osteoblasts. Furthermore, since these peptides have been extensively investigated for bone tissue engineering, the clinical applications of these peptides for bone regeneration are discussed.

Keywords: osteogenic growth peptide; bone regeneration; osteoblasts; biocompatible materials

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MDPI and ACS Style

Pigossi, S.C.; Medeiros, M.C.; Saska, S.; Cirelli, J.A.; Scarel-Caminaga, R.M. Role of Osteogenic Growth Peptide (OGP) and OGP(10–14) in Bone Regeneration: A Review. Int. J. Mol. Sci. 2016, 17, 1885. https://doi.org/10.3390/ijms17111885

AMA Style

Pigossi SC, Medeiros MC, Saska S, Cirelli JA, Scarel-Caminaga RM. Role of Osteogenic Growth Peptide (OGP) and OGP(10–14) in Bone Regeneration: A Review. International Journal of Molecular Sciences. 2016; 17(11):1885. https://doi.org/10.3390/ijms17111885

Chicago/Turabian Style

Pigossi, Suzane C., Marcell C. Medeiros, Sybele Saska, Joni A. Cirelli, and Raquel M. Scarel-Caminaga. 2016. "Role of Osteogenic Growth Peptide (OGP) and OGP(10–14) in Bone Regeneration: A Review" International Journal of Molecular Sciences 17, no. 11: 1885. https://doi.org/10.3390/ijms17111885

APA Style

Pigossi, S. C., Medeiros, M. C., Saska, S., Cirelli, J. A., & Scarel-Caminaga, R. M. (2016). Role of Osteogenic Growth Peptide (OGP) and OGP(10–14) in Bone Regeneration: A Review. International Journal of Molecular Sciences, 17(11), 1885. https://doi.org/10.3390/ijms17111885

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Role of Osteogenic Growth Peptide (OGP) and OGP(10–14) in Bone Regeneration: A Review

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