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Int. J. Mol. Sci. 2016, 17(11), 1801;

Extracellular Vesicles in Chronic Obstructive Pulmonary Disease

Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo 104-0045, Japan
Division of Respiratory Disease, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan
Author to whom correspondence should be addressed.
Academic Editor: Gregor Drummen
Received: 17 September 2016 / Revised: 19 October 2016 / Accepted: 20 October 2016 / Published: 27 October 2016
(This article belongs to the Special Issue Focus on Extracellular Vesicles)
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Chronic obstructive pulmonary disease (COPD) is characterized by the progression of irreversible airflow limitation and is a leading cause of morbidity and mortality worldwide. Although several crucial mechanisms of COPD pathogenesis have been studied, the precise mechanism remains unknown. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from almost all cell types and are recognized as novel cell–cell communication tools. They have been shown to carry and transfer a wide variety of molecules, such as microRNAs, messenger RNAs, and proteins, which are involved in physiological functions and the pathology of various diseases. Recently, EVs have attracted considerable attention in pulmonary research. In this review, we summarize the recent findings of EV-mediated COPD pathogenesis. We also discuss the potential clinical usefulness of EVs as biomarkers and therapeutic agents for the treatment of COPD. View Full-Text
Keywords: COPD; extracellular vesicles; exosome; microRNA; microvesicle; pathogenesis; biomarker; therapy; exacerbation; endothelial microparticle COPD; extracellular vesicles; exosome; microRNA; microvesicle; pathogenesis; biomarker; therapy; exacerbation; endothelial microparticle

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Kadota, T.; Fujita, Y.; Yoshioka, Y.; Araya, J.; Kuwano, K.; Ochiya, T. Extracellular Vesicles in Chronic Obstructive Pulmonary Disease. Int. J. Mol. Sci. 2016, 17, 1801.

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