Extracellular Vesicles as New Players in Cellular Senescence
1
Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123 Perugia, Italy
2
Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN), University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Gregor Drummen
Int. J. Mol. Sci. 2016, 17(9), 1408; https://doi.org/10.3390/ijms17091408
Received: 22 July 2016
/
Revised: 18 August 2016
/
Accepted: 22 August 2016
/
Published: 26 August 2016
(This article belongs to the Special Issue Focus on Extracellular Vesicles)
Cell senescence is associated with the secretion of many factors, the so-called “senescence-associated secretory phenotype”, which may alter tissue microenvironment, stimulating the organism to clean up senescent cells and replace them with newly divided ones. Therefore, although no longer dividing, these cells are still metabolically active and influence the surrounding tissue. Much attention has been recently focused not only on soluble factors released by senescent cells, but also on extracellular vesicles as conveyors of senescence signals outside the cell. Here, we give an overview of the role of extracellular vesicles in biological processes and signaling pathways related to senescence and aging.
View Full-Text
Keywords:
senescence; aging; senescence-associated secretory phenotype (SASP); extracellular vesicles; exosomes; ectosomes; microvesicles
▼
Show Figures
Graphical abstract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
MDPI and ACS Style
Urbanelli, L.; Buratta, S.; Sagini, K.; Tancini, B.; Emiliani, C. Extracellular Vesicles as New Players in Cellular Senescence. Int. J. Mol. Sci. 2016, 17, 1408. https://doi.org/10.3390/ijms17091408
AMA Style
Urbanelli L, Buratta S, Sagini K, Tancini B, Emiliani C. Extracellular Vesicles as New Players in Cellular Senescence. International Journal of Molecular Sciences. 2016; 17(9):1408. https://doi.org/10.3390/ijms17091408
Chicago/Turabian StyleUrbanelli, Lorena, Sandra Buratta, Krizia Sagini, Brunella Tancini, and Carla Emiliani. 2016. "Extracellular Vesicles as New Players in Cellular Senescence" International Journal of Molecular Sciences 17, no. 9: 1408. https://doi.org/10.3390/ijms17091408
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
