Int. J. Mol. Sci. 2016, 17(9), 1408; https://doi.org/10.3390/ijms17091408
Extracellular Vesicles as New Players in Cellular Senescence
Lorena Urbanelli 1,*
, Sandra Buratta 1, Krizia Sagini 1, Brunella Tancini 1 and Carla Emiliani 1,2,*
, Sandra Buratta 1, Krizia Sagini 1, Brunella Tancini 1 and Carla Emiliani 1,2,*
1
Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123 Perugia, Italy
2
Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN), University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Gregor Drummen
Received: 22 July 2016 / Revised: 18 August 2016 / Accepted: 22 August 2016 / Published: 26 August 2016
(This article belongs to the Special Issue Focus on Extracellular Vesicles)
Abstract
Cell senescence is associated with the secretion of many factors, the so-called “senescence-associated secretory phenotype”, which may alter tissue microenvironment, stimulating the organism to clean up senescent cells and replace them with newly divided ones. Therefore, although no longer dividing, these cells are still metabolically active and influence the surrounding tissue. Much attention has been recently focused not only on soluble factors released by senescent cells, but also on extracellular vesicles as conveyors of senescence signals outside the cell. Here, we give an overview of the role of extracellular vesicles in biological processes and signaling pathways related to senescence and aging. View Full-TextKeywords:
senescence; aging; senescence-associated secretory phenotype (SASP); extracellular vesicles; exosomes; ectosomes; microvesicles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Urbanelli, L.; Buratta, S.; Sagini, K.; Tancini, B.; Emiliani, C. Extracellular Vesicles as New Players in Cellular Senescence. Int. J. Mol. Sci. 2016, 17, 1408.
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